The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

PM Thompson, JL Stein, SE Medland, DP Hibar… - Brain imaging and …, 2014 - Springer
Abstract The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA)
Consortium is a collaborative network of researchers working together on a range of large …

[HTML][HTML] Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans

AJ Saykin, L Shen, X Yao, S Kim, K Nho… - Alzheimer's & …, 2015 - Elsevier
Introduction Genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) have
been crucial in advancing the understanding of Alzheimer's disease (AD) pathophysiology …

Brain imaging genomics: integrated analysis and machine learning

L Shen, PM Thompson - Proceedings of the IEEE, 2019 - ieeexplore.ieee.org
Brain imaging genomics is an emerging data science field, where integrated analysis of
brain imaging and genomics data, often combined with other biomarker, clinical, and …

Common disorders are quantitative traits

R Plomin, CMA Haworth, OSP Davis - Nature reviews genetics, 2009 - nature.com
After drifting apart for 100 years, the two worlds of genetics—quantitative genetics and
molecular genetics—are finally coming together in genome-wide association (GWA) …

Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans

AJ Saykin, L Shen, TM Foroud, SG Potkin… - Alzheimer's & …, 2010 - Elsevier
The role of the Alzheimer's Disease Neuroimaging Initiative Genetics Core is to facilitate the
investigation of genetic influences on disease onset and trajectory as reflected in structural …

Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort

L Shen, S Kim, SL Risacher, K Nho, S Swaminathan… - Neuroimage, 2010 - Elsevier
A genome-wide, whole brain approach to investigate genetic effects on neuroimaging
phenotypes for identifying quantitative trait loci is described. The Alzheimer's Disease …

Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease

SG Potkin, G Guffanti, A Lakatos, JA Turner, F Kruggel… - PloS one, 2009 - journals.plos.org
Background With the exception of APOE ε4 allele, the common genetic risk factors for
sporadic Alzheimer's Disease (AD) are unknown. Methods and Findings We completed a …

[HTML][HTML] ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide

PM Thompson, OA Andreassen, A Arias-Vasquez… - Neuroimage, 2017 - Elsevier
In this review, we discuss recent work by the ENIGMA Consortium (http://enigma. ini. usc.
edu)–a global alliance of over 500 scientists spread across 200 institutions in 35 countries …

APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study

VK Ramanan, SL Risacher, K Nho, S Kim… - Molecular …, 2014 - nature.com
Deposition of amyloid-β (Aβ) in the cerebral cortex is thought to be a pivotal event in
Alzheimer's disease (AD) pathogenesis with a significant genetic contribution. Molecular …

Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers

L Shen, PM Thompson, SG Potkin, L Bertram… - Brain imaging and …, 2014 - Springer
Abstract The Genetics Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI),
formally established in 2009, aims to provide resources and facilitate research related to …