Small-molecule drug discovery has traditionally focused on occupancy of a binding site that
directly affects protein function, and this approach typically precludes targeting proteins that …

Traditional pharmaceutical drug discovery is almost exclusively focused on directly
controlling protein activity to cure diseases. Modulators of protein activity, especially …

Due to its relatively easy synthesis, isoxazole ring has been as an object of interest for
chemists and pharmacologists from research groups all over the world. Its chemical …

Angiogenesis is involved in physiological and pathological processes in the body. Tumor
angiogenesis is a key factor associated with tumor growth, progression, and metastasis …

Many diseases appear to be caused by the misregulation of protein maintenance. Such
diseases of protein homeostasis, or “proteostasis,” include loss-of-function diseases (cystic …

Proteins generally must fold into precise three-dimensional conformations to fulfill their
biological functions. In the cell, this fundamental process is aided by molecular chaperones …

Photodynamic therapy (PDT) has emerged as a promising alternative to conventional
cancer therapies such as surgery, chemotherapy, and radiotherapy. PDT comprises the …

Angiogenesis has become an attractive target for drug therapy because of its key role in
tumor growth. An extensive array of compounds is currently in preclinical development, with …

Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma of which at least a subset
arises from antigen-experienced B cells. However, what role antigen stimulation plays in its …

Aneuploidy, an incorrect chromosome number, is a hallmark of cancer. Compounds that
cause lethality in aneuploid, but not euploid, cells could therefore provide new cancer …