Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
Demographic history, selection and functional diversity of the canine genome
The domestic dog represents one of the most dramatic long-term evolutionary experiments
undertaken by humans. From a large wolf-like progenitor, unparalleled diversity in …
undertaken by humans. From a large wolf-like progenitor, unparalleled diversity in …
Identification of genomic regions associated with phenotypic variation between dog breeds using selection map**
A Vaysse, A Ratnakumar, T Derrien, E Axelsson… - PLoS …, 2011 - journals.plos.org
The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique
population history accompanied by selection for novel and desirable traits. Here we perform …
population history accompanied by selection for novel and desirable traits. Here we perform …
Copy number variation of individual cattle genomes using next-generation sequencing
Copy number variations (CNVs) affect a wide range of phenotypic traits; however, CNVs in
or near segmental duplication regions are often intractable. Using a read depth approach …
or near segmental duplication regions are often intractable. Using a read depth approach …
Genome-wide analysis reveals selection for important traits in domestic horse breeds
Intense selective pressures applied over short evolutionary time have resulted in
homogeneity within, but substantial variation among, horse breeds. Utilizing this population …
homogeneity within, but substantial variation among, horse breeds. Utilizing this population …
An improved canine genome and a comprehensive catalogue of coding genes and non-coding transcripts
The domestic dog, Canis familiaris, is a well-established model system for map** trait and
disease loci. While the original draft sequence was of good quality, gaps were abundant …
disease loci. While the original draft sequence was of good quality, gaps were abundant …
Body size, inbreeding, and lifespan in domestic dogs
J Yordy, C Kraus, JJ Hayward, ME White… - Conservation …, 2020 - Springer
Inbreeding poses a real or potential threat to nearly every species of conservation concern.
Inbreeding leads to loss of diversity at the individual level, which can cause inbreeding …
Inbreeding leads to loss of diversity at the individual level, which can cause inbreeding …
Map** signatures of positive selection in the genome of livestock
Human driven selection during domestication and subsequent breed formation and
breeding has left detectable signatures within the genome of livestock breeds. The …
breeding has left detectable signatures within the genome of livestock breeds. The …
Comparative genomics as a tool to understand evolution and disease
J Alföldi, K Lindblad-Toh - Genome research, 2013 - genome.cshlp.org
When the human genome project started, the major challenge was how to sequence a 3
billion letter code in an organized and cost-effective manner. When completed, the project …
billion letter code in an organized and cost-effective manner. When completed, the project …
Intracellular hyaluronan: Importance for cellular functions
Hyaluronan-rich matrices are abundant in ECM and are involved in biological processes,
such as cell growth and migration. Hyaluronan is synthesized by the hyaluronan synthase …
such as cell growth and migration. Hyaluronan is synthesized by the hyaluronan synthase …