A novel soluble ACE2 variant with prolonged duration of action neutralizes SARS-CoV-2 infection in human kidney organoids

J Wysocki, M Ye, L Hassler, AK Gupta… - Journal of the …, 2021 - journals.lww.com
Background There is an urgent need for approaches to prevent and treat SARS-CoV-2
infection. Administration of soluble ACE2 protein acting as a decoy to bind to SARS-CoV-2 …

Extracellular vesicles as theranostic tools in kidney disease

W Huang, XY Zhu, A Lerman… - Clinical Journal of the …, 2022 - journals.lww.com
Extracellular vesicles are important vectors for cell-cell communication and show potential
value for diagnosis and treatment of kidney diseases. The pathologic diagnosis of kidney …

Human kidney spheroids and monolayers provide insights into SARS-CoV-2 renal interactions

D Omer, O Pleniceanu, Y Gnatek… - Journal of the …, 2021 - journals.lww.com
Background Although coronavirus disease 2019 (COVID-19) causes significan t morbidity,
mainly from pulmonary involvement, extrapulmonary symptoms are also major componen ts …

[HTML][HTML] Renal Proximal Tubular Epithelial Cells: From Harvesting to Use in Studies

T Petreski, L Varda, L Gradišnik, U Maver, S Bevc - Nephron, 2023 - karger.com
The kidneys are the body's main excretion organ with several additional functions, and the
nephron represents their central structural unit. It is comprised of endothelial, mesangial …

The therapeutic potential of an allosteric non‐competitive CXCR1/2 antagonist for diabetic nephropathy

C Grasselli, S Bombelli, V D'Esposito… - Diabetes/Metabolism …, 2023 - Wiley Online Library
Aims Diabetic nephropathy is a major consequence of inflammation develo** in type 1
diabetes, with interleukin‐8 (IL‐8)‐CXCR1/2 axis playing a key role in kidney disease …

Epithelial tubule interconnection driven by HGF-Met signaling in the kidney

I López-García, S Oh, C Chaney, J Tsunezumi… - Proceedings of the …, 2024 - pnas.org
The formation of functional epithelial tubules is critical for the development and maintenance
of many organ systems. While the mechanisms of tubule formation by epithelial cells are …

Physiological oxygen and co-culture with human fibroblasts facilitate in vivo-like properties in human renal proximal tubular epithelial cells

F Piossek, S Beneke, N Schlichenmaier… - Chemico-Biological …, 2022 - Elsevier
Reliable prediction of compound mediated nephrotoxicity in humans is still unsatisfactory
irrespective of the recent advancements in in silico, in vitro and in vivo models. Therefore …

Development and intra-renal delivery of renal progenitor organoids for effective integration in vivo

D Lim, I Kim, Q Song, JH Kim, A Atala… - Stem Cells …, 2024 - academic.oup.com
Renal progenitor organoids have been proposed as a source of tissue for kidney
regeneration; however, their clinical translatability has not been demonstrated due to an …

Engraftment of kidney organoids in vivo

BS Freedman, B Dekel - Current Transplantation Reports, 2023 - Springer
Abstract Purpose of Review Kidney organoids are heterocellular structures grown in vitro
that resemble nephrons. Organoids contain diverse cell types, including podocytes, proximal …

Tubular epithelial progenitors are excreted in urine during recovery from severe acute kidney injury and are able to expand and differentiate in vitro

D Gerges, Z Hevesi, SH Schmidt, S Kapps, S Pajenda… - PeerJ, 2022 - peerj.com
Background Acute kidney injury (AKI) is a serious condition associated with chronic kidney
disease, dialysis requirement and a high risk of death. However, there are specialized repair …