A novel soluble ACE2 variant with prolonged duration of action neutralizes SARS-CoV-2 infection in human kidney organoids
J Wysocki, M Ye, L Hassler, AK Gupta… - Journal of the …, 2021 - journals.lww.com
Background There is an urgent need for approaches to prevent and treat SARS-CoV-2
infection. Administration of soluble ACE2 protein acting as a decoy to bind to SARS-CoV-2 …
infection. Administration of soluble ACE2 protein acting as a decoy to bind to SARS-CoV-2 …
Extracellular vesicles as theranostic tools in kidney disease
W Huang, XY Zhu, A Lerman… - Clinical Journal of the …, 2022 - journals.lww.com
Extracellular vesicles are important vectors for cell-cell communication and show potential
value for diagnosis and treatment of kidney diseases. The pathologic diagnosis of kidney …
value for diagnosis and treatment of kidney diseases. The pathologic diagnosis of kidney …
Human kidney spheroids and monolayers provide insights into SARS-CoV-2 renal interactions
Background Although coronavirus disease 2019 (COVID-19) causes significan t morbidity,
mainly from pulmonary involvement, extrapulmonary symptoms are also major componen ts …
mainly from pulmonary involvement, extrapulmonary symptoms are also major componen ts …
[HTML][HTML] Renal Proximal Tubular Epithelial Cells: From Harvesting to Use in Studies
The kidneys are the body's main excretion organ with several additional functions, and the
nephron represents their central structural unit. It is comprised of endothelial, mesangial …
nephron represents their central structural unit. It is comprised of endothelial, mesangial …
The therapeutic potential of an allosteric non‐competitive CXCR1/2 antagonist for diabetic nephropathy
C Grasselli, S Bombelli, V D'Esposito… - Diabetes/Metabolism …, 2023 - Wiley Online Library
Aims Diabetic nephropathy is a major consequence of inflammation develo** in type 1
diabetes, with interleukin‐8 (IL‐8)‐CXCR1/2 axis playing a key role in kidney disease …
diabetes, with interleukin‐8 (IL‐8)‐CXCR1/2 axis playing a key role in kidney disease …
Epithelial tubule interconnection driven by HGF-Met signaling in the kidney
I López-García, S Oh, C Chaney, J Tsunezumi… - Proceedings of the …, 2024 - pnas.org
The formation of functional epithelial tubules is critical for the development and maintenance
of many organ systems. While the mechanisms of tubule formation by epithelial cells are …
of many organ systems. While the mechanisms of tubule formation by epithelial cells are …
Physiological oxygen and co-culture with human fibroblasts facilitate in vivo-like properties in human renal proximal tubular epithelial cells
F Piossek, S Beneke, N Schlichenmaier… - Chemico-Biological …, 2022 - Elsevier
Reliable prediction of compound mediated nephrotoxicity in humans is still unsatisfactory
irrespective of the recent advancements in in silico, in vitro and in vivo models. Therefore …
irrespective of the recent advancements in in silico, in vitro and in vivo models. Therefore …
Development and intra-renal delivery of renal progenitor organoids for effective integration in vivo
D Lim, I Kim, Q Song, JH Kim, A Atala… - Stem Cells …, 2024 - academic.oup.com
Renal progenitor organoids have been proposed as a source of tissue for kidney
regeneration; however, their clinical translatability has not been demonstrated due to an …
regeneration; however, their clinical translatability has not been demonstrated due to an …
Engraftment of kidney organoids in vivo
BS Freedman, B Dekel - Current Transplantation Reports, 2023 - Springer
Abstract Purpose of Review Kidney organoids are heterocellular structures grown in vitro
that resemble nephrons. Organoids contain diverse cell types, including podocytes, proximal …
that resemble nephrons. Organoids contain diverse cell types, including podocytes, proximal …
Tubular epithelial progenitors are excreted in urine during recovery from severe acute kidney injury and are able to expand and differentiate in vitro
D Gerges, Z Hevesi, SH Schmidt, S Kapps, S Pajenda… - PeerJ, 2022 - peerj.com
Background Acute kidney injury (AKI) is a serious condition associated with chronic kidney
disease, dialysis requirement and a high risk of death. However, there are specialized repair …
disease, dialysis requirement and a high risk of death. However, there are specialized repair …