Contralateral Breast Cancer Risk Among Carriers of Germline Pathogenic Variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2
PURPOSE To estimate the risk of contralateral breast cancer (CBC) among women with
germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2 …
germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2 …
Challenges in breast cancer genetic testing. A call for novel forms of multidisciplinary care and long-term evaluation
FH Menko, K Monkhorst, FBL Hogervorst… - Critical Reviews in …, 2022 - Elsevier
Current methods of next generation sequencing may simultaneously detect multiple
germline breast cancer susceptibility variants. However, it is a challenge to maximize the …
germline breast cancer susceptibility variants. However, it is a challenge to maximize the …
Controversies and Open Questions in Management of Cancer-Free Carriers of Germline Pathogenic Variants in BRCA1/BRCA2
R Bernstein-Molho, E Friedman, E Evron - Cancers, 2022 - mdpi.com
Simple Summary Female carriers of germline pathogenic/likely pathogenic variants
(P/LPVs) in the BRCA1/BRCA2 (BRCA) genes are at a substantially increased lifetime risk …
(P/LPVs) in the BRCA1/BRCA2 (BRCA) genes are at a substantially increased lifetime risk …
The association between age at breast cancer diagnosis and prevalence of pathogenic variants
MB Daly, E Rosenthal, S Cummings… - Breast Cancer Research …, 2023 - Springer
Purpose Young age at breast cancer (BC) diagnosis and family history of BC are strongly
associated with high prevalence of pathogenic variants (PVs) in BRCA1 and BRCA2 genes …
associated with high prevalence of pathogenic variants (PVs) in BRCA1 and BRCA2 genes …
Breast cancer susceptibility gene sequence variations and development of contralateral breast cancer
Importance Heterogeneity in development of estrogen receptor (ER)-specific first primary
breast cancer exists due to deleterious germline variants in moderate-to high-penetrance …
breast cancer exists due to deleterious germline variants in moderate-to high-penetrance …
[PDF][PDF] Germline genetic testing for women with breast cancer: shifting the paradigm from whom to test to whom NOT to test
N Tung, N Desai - Journal of Clinical Oncology, 2021 - scholar.archive.org
For women with breast cancer, the value of identifying a high-penetrance mutation in a
breast cancer gene is well-established. It provides the opportunity for contralateral …
breast cancer gene is well-established. It provides the opportunity for contralateral …
Race and site of care impact treatment delays in older women with non-metastatic breast cancer
JH Song, O Kantor, EA Mittendorf, TA King… - Annals of Surgical …, 2022 - Springer
Background Women≥ 65 years of age are less likely to receive guideline-concordant breast
cancer care. Given existing racial/ethnic disparities, older minority breast cancer patients …
cancer care. Given existing racial/ethnic disparities, older minority breast cancer patients …
Pathogenic Variants in Cancer Susceptibility Genes Predispose to Ductal Carcinoma In Situ of the Breast
Purpose: To determine the relationship between germline pathogenic variants (PV) in
cancer predisposition genes and the risk of ductal carcinoma in situ (DCIS). Experimental …
cancer predisposition genes and the risk of ductal carcinoma in situ (DCIS). Experimental …
Accurate genome-wide genoty** from archival tissue to explore the contribution of common genetic variants to pre-cancer outcomes
Purpose The contribution of common genetic variants to pre-cancer progression is
understudied due to long follow-up time, rarity of poor outcomes and lack of available …
understudied due to long follow-up time, rarity of poor outcomes and lack of available …
Mainstream germline genetic testing with expanded eligibility for early breast cancer patients in a large integrated health system
V Shim, A Karlea, LM Brenman, J Gul… - Annals of Surgical …, 2025 - Springer
Background This study evaluated a new mainstream genetic testing pathway for hereditary
cancer, with expanded eligibility for early-stage breast cancer patients. Methods The study …
cancer, with expanded eligibility for early-stage breast cancer patients. Methods The study …