Thyroid hormones are important during development of the mammalian brain, acting on
migration and differentiation of neural cells, synaptogenesis, and myelination. The actions of …

Current literature makes a distinction between two pathways for thyroid hormone signaling:
genomic and nongenomic. However, this classification is a source of confusion. We propose …

Patients with mutations in the thyroid hormone (TH) cell transporter monocarboxylate
transporter 8 (MCT8) gene develop severe neuropsychomotor retardation known as Allan …

Endothelial dysfunction is an important risk factor for cardiovascular disease, and it
represents the initial step in the pathogenesis of atherosclerosis. Failure to protect against …

Background: Normal brain development, mood, and cognitive functions depend on thyroid
hormone (TH) action. However, little is known about how TH mediates its actions in the …

Ever since the discovery of thyroid hormone deficiency as the primary cause of cretinism in
the second half of the 19th century, the crucial role of thyroid hormone (TH) signaling in …

We gathered available RNA-seq and ChIP-seq data in a single database to better
characterize the target genes of thyroid hormone receptors in several cell types. This …

Synthetic chemicals with endocrine disrupting properties are pervasive in the environment
and are present in the bodies of humans and wildlife. As thyroid hormones (THs) control …

Thyroid hormones are critical for mammalian brain development. Thus, chemicals that can
affect thyroid hormone signaling during pregnancy are of great concern. Perfluorohexane …

Thyroid hormones (TH) are crucial for brain development; their deficiency during
neurodevelopment impairs neural cell differentiation and causes irreversible neurological …