Recent advances in systems and synthetic biology approaches for develo** novel cell-factories in non-conventional yeasts

P Patra, M Das, P Kundu, A Ghosh - Biotechnology Advances, 2021 - Elsevier
Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …

[HTML][HTML] Dynamic control in metabolic engineering: Theories, tools, and applications

CJ Hartline, AC Schmitz, Y Han, F Zhang - Metabolic engineering, 2021 - Elsevier
Metabolic engineering has allowed the production of a diverse number of valuable
chemicals using microbial organisms. Many biological challenges for improving bio …

Dynamic regulation of metabolic flux in engineered bacteria using a pathway-independent quorum-sensing circuit

A Gupta, IMB Reizman, CR Reisch, KLJ Prather - Nature biotechnology, 2017 - nature.com
Metabolic engineering of microorganisms to produce desirable products on an industrial
scale can result in unbalanced cellular metabolic networks that reduce productivity and …

Quorum sensing for population-level control of bacteria and potential therapeutic applications

S Wu, J Liu, C Liu, A Yang, J Qiao - Cellular and Molecular Life Sciences, 2020 - Springer
Quorum sensing (QS), a microbial cell-to-cell communication process, dynamically regulates
a variety of metabolism and physiological activities. In this review, we provide an update on …

Advances and challenges in biotechnological production of chondroitin sulfate and its oligosaccharides

W Zhang, R Xu, J Chen, H **ong, Y Wang… - International journal of …, 2023 - Elsevier
Chondroitin sulfate (CS) is a member of glycosaminoglycans (GAGs) and has critical
physiological functions. CS is widely applied in medical and clinical fields. Currently, the …

Overcoming genetic heterogeneity in industrial fermentations

P Rugbjerg, MOA Sommer - Nature biotechnology, 2019 - nature.com
Engineering the synthesis of massive amounts of therapeutics, enzymes or commodity
chemicals can select for subpopulations of nonproducer cells, owing to metabolic burden …

[HTML][HTML] Optimization of microbial cell factories for astaxanthin production: Biosynthesis and regulations, engineering strategies and fermentation optimization …

M Basiony, L Ouyang, D Wang, J Yu, L Zhou… - Synthetic and Systems …, 2022 - Elsevier
The global market demand for natural astaxanthin is rapidly increasing owing to its safety,
the potential health benefits, and the diverse applications in food and pharmaceutical …

Layered dynamic regulation for improving metabolic pathway productivity in Escherichia coli

SJ Doong, A Gupta, KLJ Prather - Proceedings of the …, 2018 - National Acad Sciences
Microbial production of value-added chemicals from biomass is a sustainable alternative to
chemical synthesis. To improve product titer, yield, and selectivity, the pathways engineered …

Biotechnological advances for improving natural pigment production: A state-of-the-art review

X Lyu, Y Lyu, H Yu, WN Chen, L Ye, R Yang - Bioresources and …, 2022 - Springer
In current years, natural pigments are facing a fast-growing global market due to the
increase of people's awareness of health and the discovery of novel pharmacological effects …

Synthetic biology—the synthesis of biology

S Ausländer, D Ausländer… - Angewandte Chemie …, 2017 - Wiley Online Library
Synthetic biology concerns the engineering of man‐made living biomachines from
standardized components that can perform predefined functions in a (self‐) controlled …