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Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: formulation and process considerations
Spray drying is an efficient technology for solid dispersion manufacturing since it allows
extreme rapid solvent evaporation leading to fast transformation of an API-carrier solution to …
extreme rapid solvent evaporation leading to fast transformation of an API-carrier solution to …
Pharmaceutical Particle Engineering via Spray Drying
R Vehring - Pharmaceutical research, 2008 - Springer
This review covers recent developments in the area of particle engineering via spray drying.
The last decade has seen a shift from empirical formulation efforts to an engineering …
The last decade has seen a shift from empirical formulation efforts to an engineering …
Fixed-dose combination formulations in solid oral drug therapy: advantages, limitations, and design features
Whilst monotherapy is traditionally the preferred treatment starting point for chronic
conditions such as hypertension and diabetes, other diseases require the use of multiple …
conditions such as hypertension and diabetes, other diseases require the use of multiple …
Wetting, disintegration and dissolution of agglomerated water soluble powders
L Forny, A Marabi, S Palzer - Powder technology, 2011 - Elsevier
Agglomeration technologies are commonly used by the food industry to optimize several
properties such as density and flowability and also to shorten the reconstitution time of …
properties such as density and flowability and also to shorten the reconstitution time of …
Phase transition enthalpy measurements of organic and organometallic compounds and ionic liquids. Sublimation, vaporization, and fusion enthalpies from 1880 to …
W Acree, JS Chickos - Journal of Physical and Chemical Reference …, 2017 - pubs.aip.org
The second part of this compendium concludes with a collection of phase change enthalpies
of organic molecules inclusive of C 11–C 192 reported over the period 1880–2015. Also …
of organic molecules inclusive of C 11–C 192 reported over the period 1880–2015. Also …
Physical characterization and stability of amorphous indomethacin and ranitidine hydrochloride binary systems prepared by mechanical activation
Co-milling of γ-indomethacin and ranitidine hydrochloride form 2 at various weight ratios (1:
2, 1: 1 and 2: 1) was investigated with a particular interest in the physicochemical properties …
2, 1: 1 and 2: 1) was investigated with a particular interest in the physicochemical properties …
[PDF][PDF] Drug-excipient behavior in polymeric amorphous solid dispersions
Amorphous drug delivery systems are increasingly utilized to enhance aqueous solubility
and oral bioavailability. However, they lack physical and/or chemical stability. One of the …
and oral bioavailability. However, they lack physical and/or chemical stability. One of the …
Development, characterization and stabilization of amorphous form of a low Tg drug
VB Pokharkar, LP Mandpe, MN Padamwar… - Powder technology, 2006 - Elsevier
The objective of the present study was to develop a stable amorphous form of model drug
carvedilol (CAR). The amorphous material produced by melt quench technique was …
carvedilol (CAR). The amorphous material produced by melt quench technique was …
Spray-Dried Amorphous Solid Dispersions of Simvastatin, a Low Tg Drug: In Vitro and in Vivo Evaluations
AA Ambike, KR Mahadik, A Paradkar - Pharmaceutical research, 2005 - Springer
Purpose To obtain free flowing, stable, amorphous solid dispersions (SDs) of simvastatin
(SIM), a drug with relatively lower glass transition temperature (T g) by spray drying …
(SIM), a drug with relatively lower glass transition temperature (T g) by spray drying …
Effects of polymer type and storage relative humidity on the kinetics of felodipine crystallization from amorphous solid dispersions
ACF Rumondor, LA Stanford, LS Taylor - Pharmaceutical research, 2009 - Springer
Purpose The objective of this study was to investigate the effects of polymer type and
storage relative humidity (RH) on the crystallization kinetics of felodipine from amorphous …
storage relative humidity (RH) on the crystallization kinetics of felodipine from amorphous …