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Mitochondrial cristae morphology reflecting metabolism, superoxide formation, redox homeostasis, and pathology
P Ježek, M Jabůrek, B Holendová… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Mitochondrial (mt) reticulum network in the cell possesses amazing
ultramorphology of parallel lamellar cristae, formed by the invaginated inner mitochondrial …
ultramorphology of parallel lamellar cristae, formed by the invaginated inner mitochondrial …
Riding the tiger–physiological and pathological effects of superoxide and hydrogen peroxide generated in the mitochondrial matrix
Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …
wide range of physiological responses and pathologies. Concentrations of superoxide and …
Understanding coenzyme Q
Coenzyme Q (CoQ), also known as ubiquinone, comprises a benzoquinone head group and
a long isoprenoid side chain. It is thus extremely hydrophobic and resides in membranes. It …
a long isoprenoid side chain. It is thus extremely hydrophobic and resides in membranes. It …
[HTML][HTML] Hydrogen peroxide effects on natural-sourced polysacchrides: free radical formation/production, degradation process, and reaction mechanism—a critical …
Numerous reactive oxygen species (ROS) entities exist, and hydrogen peroxide (H2O2) is
very key among them as it is well known to possess a stable but poor reactivity capable of …
very key among them as it is well known to possess a stable but poor reactivity capable of …
Fatty acid oxidation drives mitochondrial hydrogen peroxide production by α-ketoglutarate dehydrogenase
In the present study, we examined the mitochondrial hydrogen peroxide (mH 2 O 2)
generating capacity of α-ketoglutarate dehydrogenase (KGDH) and compared it to …
generating capacity of α-ketoglutarate dehydrogenase (KGDH) and compared it to …
Redox activation of mitochondrial DAMPs and the metabolic consequences for development of autoimmunity
Significance: Reactive oxygen species (ROS) are well known to promote innate immune
responses during and in the absence of microbial infections. However, excessive or …
responses during and in the absence of microbial infections. However, excessive or …
[HTML][HTML] NADH/NAD+ Redox Imbalance and Diabetic Kidney Disease
Diabetic kidney disease (DKD) is a common and severe complication of diabetes mellitus. If
left untreated, DKD can advance to end stage renal disease that requires either dialysis or …
left untreated, DKD can advance to end stage renal disease that requires either dialysis or …
Reactive oxygen species generation by reverse electron transfer at mitochondrial complex I under simulated early reperfusion conditions
CT Fukushima, IS Dancil, H Clary, N Shah… - Redox Biology, 2024 - Elsevier
Ischemic tissues accumulate succinate, which is rapidly oxidized upon reperfusion, driving a
burst of mitochondrial reactive oxygen species (ROS) generation that triggers cell death. In …
burst of mitochondrial reactive oxygen species (ROS) generation that triggers cell death. In …
Site IQ in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions
Superoxide/hydrogen peroxide production by site IQ in complex I of the electron transport
chain is conventionally assayed during reverse electron transport (RET) from ubiquinol to …
chain is conventionally assayed during reverse electron transport (RET) from ubiquinol to …
How the disruption of mitochondrial redox signalling contributes to ageing
In the past, mitochondrial reactive oxygen species (mtROS) were considered a byproduct of
cellular metabolism. Due to the capacity of mtROS to cause oxidative damage, they were …
cellular metabolism. Due to the capacity of mtROS to cause oxidative damage, they were …