RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor
suppressor whose inactivation is implicated in the development of many human cancers …

MAP1-family proteins are classical microtubule-associated proteins (MAPs) that bind along
the microtubule lattice. The founding members, MAP1A and MAP1B, are predominantly …

The Ras-Association Domain Family (RASSF) comprises ten members, termed RASSF1 to
RASSF10. RASSF1 to RASSF6 harbor a C-terminal Ras-association (RA) domain and …

Nasopharyngeal carcinoma (NPC) is consistently associated with EBV infection and
prevalence in southern China and Southeast Asia. In addition to EBV, the development of …

Ras proteins play a direct causal role in human cancer with activating mutations in Ras
occurring in∼ 30% of tumours. Ras effectors also contribute to cancer, as mutations occur in …

Early observations of centrosomes, made a century ago, revealed a tiny dark structure
surrounded by a radial array of cytoplasmic fibers. We now know that the fibers are …

Genetic changes through allelic loss and nucleic acid or protein modifications are the main
contributors to loss of function of tumor suppressor proteins. In particular, epigenetic …

Abstract Mammalian sterile 20–like kinase 1 (Mst1) is activated by both caspase-mediated
cleavage and phosphorylation in response to apoptotic stimuli, including Fas ligation. Here …

Tissue homeostasis is controlled by signaling systems that coordinate cell proliferation, cell
growth and cell shape upon changes in the cellular environment. Deregulation of these …

Persistent inflammation can trigger altered epigenetic, inflammatory, and bioenergetic
states. Inflammatory bowel disease (IBD) is an idiopathic disease characterized by chronic …