C–H deuteration has been intricately developed to satisfy the urgent need for site-selectively
deuterated organic frameworks. Deuteration has been primarily used to study kinetic isotope …

Deuterated and tritiated analogs of drugs are valuable compounds for pharmaceutical and
medicinal chemistry. In this work, we present a novel hydrogen isotope exchange reaction of …

Phthalimidine finds wide pharmaceutical applications and its deuterated derivative is
supposed to exhibit enhanced stability towards metabolism. In this work, an …

Using D2O as a deuterium source, a method for the deuteration of intra-and extra-cyclic
methylene has been developed for cyclic ethers with moderate yield and excellent …

Direct formylation of feedstock indoles with newly developed, cost-effective deuterated
glyoxylic acid as formylation agent under visible light and air (O2) as terminal oxidant has …

A Pd-catalyzed regioselective H/D exchange at the α-position of pyridines was achieved by
employing secondary phosphine oxide as an internal base. The proposed five-membered …

A regioselective deuteration at the β-and γ-position of pyridines is reported. Efficient
deuteration occurred with a combination of KOtBu and DMSO-d6, replenishing the …

A nickel-catalyzed hydrogen isotope exchange has been developed with acetone-d6 as the
deuterium source. The reaction showed an improved kinetic feature of H/D exchange under …

Silver-catalyzed deuteration of nitroaromatics has been achieved using D2O as the
deuterium source. Distinct from the well-established directing group-guided hydrogen …

As a representative scaffold of alkaloids, indoles have been extensively subjected to
deuteration, but the regioselective C4 labeling has not been achieved due to its low …