Regulatory T cells (Treg) are essential to maintain immune homeostasis and prevent
autoimmune disorders. While the function and molecular regulation of Foxp3+ CD4+ Tregs …

Regulatory T cells (Tregs) play a key role in the peripheral self‐tolerance and preventing
autoimmunity. While classical CD4+ Foxp3+ Tregs are well established, their CD8+ …

Transplantation of solid organs can be life-saving in patients with end-stage organ failure,
however, graft rejection remains a major challenge. In this study, by pre-conditioning with …

Dendritic cells (DCs) are the major specialized antigen-presenting cells (APCs), play a key
role in initiating the body's immune response, maintain the balance of immunity. DCs can …

Background Myasthenia gravis (MG) and the experimental autoimmune MG (EAMG) animal
model are characterized by T-cell-induced and B-cell-dominated autoimmune diseases that …

Radiotherapy (RT) is commonly employed to treat solid tumors. Immune checkpoint
blockade of programmed cell death protein 1 (PD-1) and CTLA-4 improves survival in RT …

Hepatocellular carcinoma (HCC) is a tumor that exhibits glucometabolic reprogramming,
with a high incidence and poor prognosis. Usually, HCC is not discovered until an advanced …

Background Celiac disease (CD) is an autoimmune disorder triggered by gluten
consumption. Almost all CD patients possess human leukocyte antigen (HLA) DQ2/DQ8 …

CD4+ Foxp3+ regulatory T cells (Tregs) are indispensable for preventing autoimmunity, and
they play a role in cancer and transplantation settings by restraining immune responses. In …

Regulation of the adaptive immune response is critical for health. Regulatory activity can be
found in multiple components of the immune system, however, the focus on particular …