Protein crystallography using synchrotron radiation sources has had a tremendous impact
on biology, having yielded the structures of thousands of proteins and given detailed insight …

Many of the proposed applications of metal–organic framework (MOF) materials may fail to
materialize if the community does not fully address the difficult fundamental work needed to …

Photosynthesis converts light energy into biologically useful chemical energy vital to life on
Earth. The initial reaction of photosynthesis takes place in photosystem II (PSII), a 700 …

Structure determination of proteins and other macromolecules has historically required the
growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding …

The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of
delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of …

MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory
cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms …

X-ray free-electron lasers have opened up the possibility of structure determination of
protein crystals at room temperature, free of radiation damage. The femtosecond-duration …

Radiation damage inflicted during diffraction data collection in macromolecular
crystallography has re-emerged in the last decade as a major experimental and …

We report a method of femtosecond crystallography for solving radiation damage–free
crystal structures of large proteins at sub-angstrom spatial resolution, using a large single …

A new approach for collecting data from many hundreds of thousands of microcrystals using
X-ray pulses from a free-electron laser has recently been developed. Referred to as serial …