The skin serves as the primary interface between our body and the external environment
and acts as a barrier against entry of physical agents, chemicals, and microbes …

Type I interferons have been suspected for decades to have a crucial role in the
pathogenesis of systemic lupus erythematosus (SLE). Evidence has now overturned several …

Cutaneous lupus erythematosus (CLE) is a disfiguring and poorly understood condition
frequently associated with systemic lupus. Previous studies suggest that nonlesional …

Objectives To characterise the efficacy and safety of anifrolumab in patients with systemic
lupus erythematosus (SLE) according to interferon gene signature (IFNGS), demographic …

The type I interferon pathway has been implicated in the pathogenesis of a number of
rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis …

Objective Skin inflammation and photosensitivity are common in patients with cutaneous
lupus erythematosus (CLE) and systemic lupus erythematosus (SLE), yet little is known …

Autoimmune connective tissue diseases arise in a stepwise fashion from asymptomatic
preclinical autoimmunity. Type I interferons have a crucial role in the progression to …

Cutaneous lupus erythematosus (CLE) is an autoimmune disease that can present as an
isolated skin disease or as a manifestation within the spectrum of systemic lupus …

Type I interferons, which make up the first cytokine family to be described and are the
essential mediators of antivirus host defense, have emerged as central elements in the …

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease
characterized by dysregulated immune responses leading to widespread inflammation and …