Community-acquired bacterial meningitis

D van de Beek, M Brouwer, R Hasbun… - Nature reviews Disease …, 2016‏ - nature.com
Meningitis is an inflammation of the meninges and subarachnoid space that can also involve
the brain cortex and parenchyma. It can be acquired spontaneously in the community …

Making sense of differences in pneumococcal serotype replacement

JA Lewnard, WP Hanage - The Lancet Infectious Diseases, 2019‏ - thelancet.com
Serotype replacement in invasive pneumococcal disease threatens to undermine the most
costly vaccination programme currently undertaken. However, the effects of replacement on …

Rapid increase in non-vaccine serotypes causing invasive pneumococcal disease in England and Wales, 2000–17: a prospective national observational cohort study

SN Ladhani, S Collins, A Djennad… - The Lancet Infectious …, 2018‏ - thelancet.com
Summary Background Pneumococcal conjugate vaccines (PCVs) have substantially
reduced the incidence of invasive pneumococcal disease caused by vaccine serotypes; …

Impact of 13-valent pneumococcal conjugate vaccination in invasive pneumococcal disease incidence and mortality

ZB Harboe, T Dalby, DM Weinberger… - Clinical Infectious …, 2014‏ - academic.oup.com
Background. The impact of the 13-valent pneumococcal conjugate vaccine (PCV13) at the
population level is unclear. We explored PCV13's effect in reducing invasive pneumococcal …

Pneumococcal serotypes before and after introduction of conjugate vaccines, United States, 1999–2011

SS Richter, KP Heilmann, CL Dohrn… - Emerging infectious …, 2013‏ - pmc.ncbi.nlm.nih.gov
Seroty** data for pneumococci causing invasive and noninvasive disease in 2008–2009
and 2010–2011 from> 43 US centers were compared with data from preconjugate vaccine …

Effect of pneumococcal conjugate vaccination on serotype-specific carriage and invasive disease in England: a cross-sectional study

S Flasche, AJ Van Hoek, E Sheasby, P Waight… - PLoS …, 2011‏ - journals.plos.org
Background We investigated the effect of the 7-valent pneumococcal conjugate vaccine
(PCV7) programme in England on serotype-specific carriage and invasive disease to help …

[PDF][PDF] Clinical implications of pneumococcal serotypes: invasive disease potential, clinical presentations, and antibiotic resistance

JY Song, MH Nahm… - Journal of Korean medical …, 2013‏ - synapse.koreamed.org
Streptococcus pneumoniae can asymptomatically colonize the nasopharynx and cause a
diverse range of illnesses. This clinical spectrum from colonization to invasive …

The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia

M Witzenrath, F Pache, D Lorenz, U Koppe… - The Journal of …, 2011‏ - journals.aai.org
Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, and sepsis.
Pneumococci can be divided into> 90 serotypes that show differences in the pathogenicity …

Recognition of Streptococcus pneumoniae by the innate immune system

U Koppe, N Suttorp, B Opitz - Cellular microbiology, 2012‏ - Wiley Online Library
Streptococcus pneumoniae is both a frequent colonizer of the upper respiratory tract and a
leading cause of life‐threatening infections such as pneumonia, meningitis and sepsis. The …

Streptococcus pneumoniae serotype 19A: worldwide epidemiology

R Isturiz, HL Sings, B Hilton, A Arguedas… - Expert review of …, 2017‏ - Taylor & Francis
Introduction: Streptococcus pneumoniae causes mucosal and invasive diseases with high
morbidity and mortality. Introduction of the 7-valent pneumococcal conjugate vaccine …