Surely most chronobiologists believe circadian clocks are an adaptation of organisms that
enhances fitness, but are we certain that this focus of our research effort really confers a …

Daily rhythms in behavior, physiology and metabolism are controlled by endogenous
circadian clocks. At the heart of these clocks is a circadian oscillator that keeps circadian …

Circadian (∼ 24 h) clock regulated biological rhythms have been identified in a wide range
of organisms from prokaryotic unicellular cyanobacteria to higher mammals. These rhythms …

Biological pacemakers dictate our daily schedules in physiology and behaviour. The
molecules, cells and networks that underlie these circadian rhythms can now be monitored …

Although it is well established that the circadian clock regulates mammalian reproductive
physiology, the molecular mechanisms by which this regulation occurs are not clear. The …

Circadian clocks are believed to have evolved in parallel with the geological history of the
earth, and have since been fine-tuned under selection pressures imposed by cyclic factors …

Many aspects of human health and disease display daily rhythmicity. The brain's
suprachiasmic nucleus, which interprets recurring external stimuli, and autonomous …

Circadian rhythms are believed to be an evolutionary adaptation to daily environmental
cycles resulting from Earth's rotation about its axis. A trait evolved through a process of …

Rhythmic events in the female reproductive system depend on the coordinated and
synchronized activity of multiple neuroendocrine and endocrine tissues. This coordination is …

TIMELESS (TIM) was first identified as a molecular cog in the Drosophila circadian clock.
Almost three decades of investigations have resulted in an insightful model describing the …