Cryo–electron microscopy, or simply cryo-EM, refers mainly to three very different yet closely
related techniques: electron crystallography, single-particle cryo-EM, and electron …

This review highlights recent efforts on applying electron microscopy (EM) to soft (including
biological) nanomaterials. We will show how developments of both the hardware and …

A new method to estimate the trajectories of particle motion and the amount of cumulative
beam damage in electron cryo-microscopy (cryo-EM) single-particle analysis is presented …

Biological specimens suffer radiation damage when imaged in an electron microscope,
ultimately limiting the attainable resolution. At a given resolution, an optimal exposure can …

For many years, structure determination of biological macromolecules by cryo-electron
microscopy (cryo-EM) was limited to large complexes or low-resolution models. With recent …

In 2013 we established a cryo-electron microscopy (cryo-EM) technique called microcrystal
electron diffraction (MicroED). Since that time, data collection and analysis schemes have …

Cryo-electron microscopy of vitrified specimens was just emerging as a practical method
when Richard Henderson proposed that we should teach an EMBO course on the new …

We demonstrate that it is feasible to determine high-resolution protein structures by electron
crystallography of three-dimensional crystals in an electron cryo-microscope (CryoEM) …

The revolution will not be crystallized: a new method sweeps through structural biology |
Nature Skip to main content Thank you for visiting nature.com. You are using a browser version …

The aim of this book is to outline the physics of image formation, electron specimen
interactions and image interpretation in transmission electron mic roscopy. The book …