Rhythmic and effective cardiac contraction depends on appropriately timed generation and
spread of cardiac electrical activity. The basic cellular unit of such activity is the action …

Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …

Cardiomyocyte function depends on coordinated movements of calcium into and out of the
cell and the proper delivery of ATP to energy-utilizing enzymes. Defects in calcium-handling …

SR Houser, V. Piacentino III and J. Weisser. Abnormalities of Calcium Cycling in the
Hypertrophied and Failing Heart. Journal of Molecular and Cellular Cardiology (2000) 32 …

Background—Abnormal Ca2+ handling may contribute to impaired atrial contractility and
arrhythmogenesis in human chronic atrial fibrillation (cAF). Here, we assessed the …

Aims It is generally accepted that post-MI heart failure (HF) changes a variety of aspects of
sarcoplasmic reticular Ca2+ fluxes but for some aspects there is disagreement over whether …

Cardiac myocyte function is dependent on the synchronized movements of Ca2+ into and
out of the cell, as well as between the cytosol and sarcoplasmic reticulum. These …

The δ isoform of Ca 2+/calmodulin-dependent protein kinase II (CaMKII) predominates in the
heart. To investigate the role of CaMKII in cardiac function, we made transgenic (TG) mice …