Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology

LGN de Almeida, H Thode, Y Eslambolchi… - Pharmacological …, 2022 - Elsevier
The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Matrix metalloproteinases as modulators of inflammation and innate immunity

WC Parks, CL Wilson, YS López-Boado - Nature Reviews Immunology, 2004 - nature.com
As their name implies, matrix metalloproteinases are thought to be responsible for the
turnover and degradation of the extracellular matrix. However, matrix degradation is neither …

Devices and methods for applying bolster materials to surgical fastening apparatuses

B Shah, JW Zubik - US Patent 8,956,390, 2015 - Google Patents
BACKGROUND The present invention relates generally to medical devices 15 and in
particular aspects to devices and methods that are useful for applying bolster materials to …

Absorbable adhesives and their formulation for use in medical applications

B Shah, PJ Hall - US Patent 10,500,309, 2019 - Google Patents
Described are medical products including an adhesive containing a polypeptide component
such as gelatin and a tackiness-providing polyhydroxy compound, such as at least one …

The biology of eosinophils and their role in asthma

CN McBrien, A Menzies-Gow - Frontiers in medicine, 2017 - frontiersin.org
This review will describe the structure and function of the eosinophil. The roles of several
relevant cell surface molecules and receptors will be discussed. We will also explore the …

Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases

J Hu, PE Van den Steen, QXA Sang… - Nature reviews Drug …, 2007 - nature.com
Matrix metalloproteinases (MMPs) have outgrown the field of extracellular-matrix biology
and have progressed towards being important regulatory molecules in cancer and …

Expression and function of laminins in the embryonic and mature vasculature

R Hallmann, N Horn, M Selg, O Wendler… - Physiological …, 2005 - journals.physiology.org
Endothelial cells of the blood and lymphatic vasculature are polarized cells with luminal
surfaces specialized to interact with inflammatory cells upon the appropriate stimulation; …

Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes

DK **, K Shido, HG Kopp, I Petit, SV Shmelkov… - Nature medicine, 2006 - nature.com
The mechanisms through which hematopoietic cytokines accelerate revascularization are
unknown. Here, we show that the magnitude of cytokine-mediated release of SDF-1 from …

Airway remodelling in asthma: from benchside to clinical practice

C Bergeron, MK Tulic, Q Hamid - Canadian respiratory journal, 2010 - Wiley Online Library
Airway remodelling refers to the structural changes that occur in both large and small
airways relevant to miscellaneous diseases including asthma. In asthma, airway structural …

Macrophage roles following myocardial infarction

JM Lambert, EF Lopez, ML Lindsey - International journal of cardiology, 2008 - Elsevier
Following myocardial infarction (MI), circulating blood monocytes respond to chemotactic
factors, migrate into the infarcted myocardium, and differentiate into macrophages. At the …