The establishing of the first cancer models created a new perspective on the identification
and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft …

Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an
ongoing inflammatory response. Recent advances in basic science have established a …

Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly
supplanting long-established traditional cell lines as preferred models for conducting basic …

To establish a more appropriate animal recipient for xenotransplantation, NOD/SCID/γ c null
mice double homozygous for the severe combined immunodeficiency (SCID) mutation and …

The culmination of decades of research on humanized mice is leading to advances in our
understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity …

The nonobese diabetic/severe combined immune deficiency (NOD-scid)
xenotransplantation model is the “gold standard” for assaying human hematopoietic stem …

“Humanized” mouse models created by engraftment of immunodeficient mice with human
hematolymphoid cells or tissues are an emerging technology with broad appeal across …

The discovery of the severe combined immunodeficiency (scid) mouse mutation has
provided a tool for establishment of small animal models as hosts for the in vivo analysis of …

Immunodeficient mice engrafted with human cells and tissues have provided an exciting
alternative to in vitro studies with human tissues and nonhuman primates for the study of …

The study of human-specific infectious agents has been hindered by the lack of optimal
small animal models. More recently development of novel strains of immunodeficient mice …