Melatonin: A master regulator of plant development and stress responses

C Sun, L Liu, L Wang, B Li, C **… - Journal of Integrative …, 2021 - Wiley Online Library
Melatonin is a pleiotropic molecule with multiple functions in plants. Since the discovery of
melatonin in plants, numerous studies have provided insight into the biosynthesis …

Melatonin as an antioxidant: under promises but over delivers

RJ Reiter, JC Mayo, DX Tan, RM Sainz… - Journal of pineal …, 2016 - Wiley Online Library
Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large
number of circumstances. It achieves this action via a variety of means: direct detoxification …

Melatonin and phytomelatonin: Chemistry, biosynthesis, metabolism, distribution and bioactivity in plants and animals—An overview

G Mannino, C Pernici, G Serio, C Gentile… - International Journal of …, 2021 - mdpi.com
Melatonin is a ubiquitous indolamine, largely investigated for its key role in the regulation of
several physiological processes in both animals and plants. In the last century, it was …

Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas

RJ Reiter, S Rosales-Corral, DX Tan, MJ Jou… - Cellular and molecular …, 2017 - Springer
Melatonin is an ancient antioxidant. After its initial development in bacteria, it has been
retained throughout evolution such that it may be or may have been present in every species …

Capture of hydroxyl radicals by hydronium cations in water microdroplets

D **ng, Y Meng, X Yuan, S **, X Song… - Angewandte …, 2022 - Wiley Online Library
Despite the high stability of bulk water, water microdroplets possess strikingly different
properties, such as the presence of hydroxyl radicals (OH⋅) at the air–water interface …

Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection

A Galano, RJ Reiter - Journal of Pineal Research, 2018 - Wiley Online Library
Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …

Extrapineal melatonin: sources, regulation, and potential functions

D Acuña-Castroviejo, G Escames, C Venegas… - Cellular and molecular …, 2014 - Springer
Endogenous melatonin is synthesized from tryptophan via 5-hydroxytryptamine. It is
considered an indoleamine from a biochemical point of view because the melatonin …

Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions

HM Zhang, Y Zhang - Journal of pineal research, 2014 - Wiley Online Library
Abstract Melatonin (N‐acetyl‐5‐methoxytryptamine), an indoleamine produced in many
organs including the pineal gland, was initially characterized as a hormone primarily …

Oxidative stress in amyotrophic lateral sclerosis: pathophysiology and opportunities for pharmacological intervention

T Cunha-Oliveira, L Montezinho… - Oxidative medicine …, 2020 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease or Charcot
disease, is a fatal neurodegenerative disease that affects motor neurons (MNs) and leads to …

The involvement of the oxidative stress status in cancer pathology: a double view on the role of the antioxidants

KF Zahra, R Lefter, A Ali, EC Abdellah… - Oxidative Medicine …, 2021 - Wiley Online Library
Oxygen‐free radicals, reactive oxygen species (ROS) or reactive nitrogen species (RNS),
are known by their “double‐sided” nature in biological systems. The beneficial effects of …