The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …

Over the last decade, the development and prevalence of obesity have posed a serious
public health risk, which has prompted studies on the regulation of adiposity. With the ease …

Dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. But
the mechanisms by which MUFAs extend lifespan remain unclear. Here we show that an …

Dietary restriction (DR) delays aging and the onset of age-associated diseases. However, it
is yet to be determined whether and how restriction of specific nutrients promote longevity …

As developmental biologists in the age of genome editing, we now have access to an ever-
increasing array of tools to manipulate endogenous gene expression. The auxin-inducible …

The proper maintenance of mRNA quality that is regulated by diverse surveillance pathways
is essential for cellular homeostasis and is highly conserved among eukaryotes. Here, we …

Aging is a primary risk factor for neurodegenerative disorders that involve protein
aggregation. Because lowering body temperature is one of the most effective mechanisms to …

Polyphenism is a type of developmental plasticity that translates continuous environmental
variability into discontinuous phenotypes. Such discontinuity likely requires a switch …

Temperature is a critical environmental cue that controls the development and lifespan of
many animal species; however, mechanisms underlying low-temperature adaptation are …

Caffeic acid (CA), a derivative of cinnamic acid, exists in various vegetables and fruits.
Natural compounds as beneficial antioxidants play an important role in the research of …