Pyrazole containing natural products: Synthetic preview and biological significance
A large number of structurally diverse natural compounds containing azole nucleus
constitute an important class of biologically active heterocycles that are gaining more …
constitute an important class of biologically active heterocycles that are gaining more …
Trifluoromethylpyrazoles as anti-inflammatory and antibacterial agents: A review
In the recent past trifluoromethylpyrazoles have gained much attention, particularly as anti-
inflammatory and antibacterial agents, in the field of medicinal chemistry. The location of …
inflammatory and antibacterial agents, in the field of medicinal chemistry. The location of …
Cycloaddition of Trifluoroacetaldehyde N-Triftosylhydrazone (TFHZ-Tfs) with Alkynes for Synthesizing 3-Trifluoromethylpyrazoles
H Wang, Y Ning, Y Sun, P Sivaguru, X Bi - Organic letters, 2020 - ACS Publications
A transition-metal-free [3+ 2] cycloaddition between trifluoroacetaldehyde N-
triftosylhydrazone (TFHZ-Tfs) and alkynes is reported. This protocol provides an …
triftosylhydrazone (TFHZ-Tfs) and alkynes is reported. This protocol provides an …
Repurposing celecoxib as a topical antimicrobial agent
There is an urgent need for new antibiotics and alternative strategies to combat multidrug-
resistant bacterial pathogens, which are a growing clinical issue. Repurposing existing …
resistant bacterial pathogens, which are a growing clinical issue. Repurposing existing …
Pyrazoles as potential anti-angiogenesis agents: a contemporary overview
Angiogenesis is a mulit-step process by which new blood vessels are formed from
preexisting vasculature. It is a key rate limiting factor in tumor growth since new blood …
preexisting vasculature. It is a key rate limiting factor in tumor growth since new blood …
Synthesis, antimicrobial and antioxidant activity of pyrazole based sulfonamide derivatives
JR Badgujar, DH More, JS Meshram - Indian journal of microbiology, 2018 - Springer
A series of new sulfonamides have been synthesized from Ampyrone with different benzene
sulfonyl chlorides to yield the N-1, 5-dimethyl-3-oxo-2-phenyl-2, 3-dihydro-1 H-pyrazol-4-yl) …
sulfonyl chlorides to yield the N-1, 5-dimethyl-3-oxo-2-phenyl-2, 3-dihydro-1 H-pyrazol-4-yl) …
Fluorinated isoxazolines and isoxazoles: A synthetic perspective
V Kumar, K Kaur - Journal of Fluorine Chemistry, 2015 - Elsevier
Isoxazoline and isoxazole derivatives are an important class of nitrogen and oxygen
containing heterocycles that are well known to display an array of various biological …
containing heterocycles that are well known to display an array of various biological …
Synthesis and biological evaluation of some 2-(3, 5-dimethyl-1H-pyrazol-1-yl)-1-arylethanones: Antibacterial, DNA photocleavage, and anticancer activities
In continuation of our efforts to find new biologically active agents, regioselective synthesis
of a series of 2-(3, 5-dimethyl-1H-pyrazol-1-yl)-1-arylethanones 4a–k has been achieved …
of a series of 2-(3, 5-dimethyl-1H-pyrazol-1-yl)-1-arylethanones 4a–k has been achieved …
Discovery of novel pyridazine-based cyclooxygenase-2 inhibitors with a promising gastric safety profile
Cyclooxygenase-2 (COX-2) is implicated in the development of chronic inflammatory
diseases. Recently, pyridazine derivatives have emerged as a novel prototype to develop …
diseases. Recently, pyridazine derivatives have emerged as a novel prototype to develop …
Recent Developments and Challenges in the Enzymatic Formation of Nitrogen–Nitrogen Bonds
C Angeli, S Atienza-Sanz, S Schröder, A Hein… - ACS …, 2024 - ACS Publications
The biological formation of nitrogen–nitrogen (N–N) bonds represents intriguing reactions
that have attracted much attention in the past decade. This interest has led to an increasing …
that have attracted much attention in the past decade. This interest has led to an increasing …