The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Here, we present the synthesis and characterization of statistical and block copolymers
containing α-lipoic acid (LA) using reversible addition–fragmentation chain-transfer (RAFT) …

Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …

Dynamic covalent bonds (DCBs) have received widespread attention due to their unique
reversibility and stimulus responsiveness. The introduction of DCBs often endows materials …

Enabling the cellular delivery and cytosolic bioavailability of functional proteins constitutes a
major challenge for the life sciences. Here we demonstrate that thiol-reactive arginine-rich …

Sulfur and its functional groups are major players in an area of exciting research taking
place in modern polymer and materials science, both in academia and industry. In fact …

Efficient cellular delivery of biologically active molecules is one of the key factors that affect
the discovery and development of novel drugs. The plasma membrane is the first barrier that …

Protein/antibody therapeutics have exhibited the advantages of high specificity and activity
even at an extremely low concentration compared to small molecule drugs. However, they …

This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …