Hemodialysis has saved many lives, albeit with significant residual mortality. Although poor
outcomes may reflect advanced age and comorbid conditions, hemodialysis per se may …

Abstract Background and Objective: Cardiac electrophysiology is a medical specialty with a
long and rich tradition of computational modeling. Nevertheless, no community standard for …

Advanced computational techniques and mathematical modeling have become more and
more important to the study of cardiac electrophysiology. In this review, we provide a brief …

BACKGROUND: Transfusion of citrated blood products may worsen resuscitation-induced
hypocalcemia and trauma outcomes, suggesting the need for protocolized early calcium …

Computer modeling of the electrophysiology of the heart has undergone significant
progress. A healthy heart can be modeled starting from the ion channels via the spread of a …

Digitization of healthcare will be a major innovation driver in the coming decade. Also,
enabled by technological advancements and electronics miniaturization, wearable health …

Diseases caused by alterations of ionic concentrations are frequently observed challenges
and play an important role in clinical practice. The clinically established method for the …

The sinoatrial node (SAN) is a complex structure that spontaneously depolarizes
rhythmically (" pacing") and excites the surrounding non-automatic cardiac cells (" drive") to …

Sinus node (SN) pacemaking is based on a coupling between surface membrane ion-
channels and intracellular Ca2+-handling. The fundamental role of the inward Na+/Ca2+ …

Background: The mechanisms underlying dysfunction in the sinoatrial node (SAN), the
heart's primary pacemaker, are incompletely understood. Electrical and Ca2+-handling …