The mononuclear phagocyte system comprises a network of circulating monocytes and
dendritic cells (DCs), and “histiocytes”(tissue-resident macrophages and DCs) that are …

Vascular cell adhesion is a complex orchestration of events that commonly feature lectin–
ligand interactions between circulating cells, such as immune, stem, and tumor cells, and …

Glycans decorating cell surface and secreted proteins and lipids occupy the juncture where
critical host–host and host-pathogen interactions occur. The role of glycan epitopes in cell …

Breast cancer tissue overexpresses fucosylated glycans, such as sialyl‐Lewis X/A (sLeX/A),
and α‐1, 3/4‐fucosyltransferases (FUTs) in relation to increased disease progression and …

The human acute monocytic leukemia cell line THP-1 is widely used as an in vitro
phagocytic cell model because it exhibits several immune properties similar to native …

Abstract Purpose The carbohydrate sialyl Lewis X (sLe X) mediates cell adhesion, is critical
in the normal function of immune cells, and is frequently over-expressed on cancer cells. We …

Dendritic cells (DC s) play an essential role in immunity against bacteria by phagocytosis
and by eliciting adaptive immune responses. Previously, we demonstrated that human …

Both host defense and immunopathology are shaped by the ordered recruitment of
circulating leukocytes to affected sites, a process initiated by binding of blood-borne cells to …

Macrophage glycosylation is essential to initiate the host-immune defense but may also be
targeted by pathogens to promote infection. Indeed, the alteration of the cell-surface …

The mechanisms underlying neurodegeneration in Parkinson's disease (PD) are still not
fully understood. Glycosylation is an important post-translational modification that affects …