Single-molecule localization microscopy
Single-molecule localization microscopy (SMLM) describes a family of powerful imaging
techniques that dramatically improve spatial resolution over standard, diffraction-limited …
techniques that dramatically improve spatial resolution over standard, diffraction-limited …
A review of super-resolution single-molecule localization microscopy cluster analysis and quantification methods
Single-molecule localization microscopy (SMLM) is a relatively new imaging modality,
winning the 2014 Nobel Prize in Chemistry, and considered as one of the key super …
winning the 2014 Nobel Prize in Chemistry, and considered as one of the key super …
Membrane phase separation drives responsive assembly of receptor signaling domains
Plasma membrane heterogeneity has been tied to a litany of cellular functions and is often
explained by analogy to membrane phase separation; however, models based on phase …
explained by analogy to membrane phase separation; however, models based on phase …
A trans-synaptic nanocolumn aligns neurotransmitter release to receptors
Synaptic transmission is maintained by a delicate, sub-synaptic molecular architecture, and
even mild alterations in synapse structure drive functional changes during experience …
even mild alterations in synapse structure drive functional changes during experience …
Measuring image resolution in optical nanoscopy
Resolution in optical nanoscopy (or super-resolution microscopy) depends on the
localization uncertainty and density of single fluorescent labels and on the sample's spatial …
localization uncertainty and density of single fluorescent labels and on the sample's spatial …
Phosphatidylserine vesicles enable efficient en bloc transmission of enteroviruses
YH Chen, WL Du, MC Hagemeijer, PM Takvorian… - Cell, 2015 - cell.com
A central paradigm within virology is that each viral particle largely behaves as an
independent infectious unit. Here, we demonstrate that clusters of enteroviral particles are …
independent infectious unit. Here, we demonstrate that clusters of enteroviral particles are …
Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
Damage-induced long non-coding RNAs (dilncRNA) synthesized at DNA double-strand
breaks (DSBs) by RNA polymerase II are necessary for DNA-damage-response (DDR) focus …
breaks (DSBs) by RNA polymerase II are necessary for DNA-damage-response (DDR) focus …
Force loading explains spatial sensing of ligands by cells
Cells can sense the density and distribution of extracellular matrix (ECM) molecules by
means of individual integrin proteins and larger, integrin-containing adhesion complexes …
means of individual integrin proteins and larger, integrin-containing adhesion complexes …
ecDNA hubs drive cooperative intermolecular oncogene expression
Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high
expression of oncogenes through gene amplification and altered gene regulation. Gene …
expression of oncogenes through gene amplification and altered gene regulation. Gene …
CDK7 inhibition potentiates genome instability triggering anti-tumor immunity in small cell lung cancer
Summary Cyclin-dependent kinase 7 (CDK7) is a central regulator of the cell cycle and gene
transcription. However, little is known about its impact on genomic instability and cancer …
transcription. However, little is known about its impact on genomic instability and cancer …