Current clinical applications of in vivo gene therapy with AAVs
Hereditary diseases are caused by mutations in genes, and more than 7,000 rare diseases
affect over 30 million Americans. For more than 30 years, hundreds of researchers have …
affect over 30 million Americans. For more than 30 years, hundreds of researchers have …
Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease
In this modern era, with the help of various advanced technologies, medical science has
overcome most of the health-related issues successfully. Though, some diseases still remain …
overcome most of the health-related issues successfully. Though, some diseases still remain …
[HTML][HTML] Gene therapy for neurodegenerative diseases
Gene therapy has the potential to provide therapeutic benefit to millions of people with
neurodegenerative diseases through several means, including direct correction of …
neurodegenerative diseases through several means, including direct correction of …
Adeno-associated viral vector (serotype 2)–nerve growth factor for patients with alzheimer disease: a randomized clinical trial
Importance Nerve growth factor (NGF) is an endogenous neurotrophic factor that prevents
the death and augments the functional state of cholinergic neurons of the basal forebrain, a …
the death and augments the functional state of cholinergic neurons of the basal forebrain, a …
Neurotrophic factors in Alzheimer's and Parkinson's disease brain
GJ Siegel, NB Chauhan - Brain Research Reviews, 2000 - Elsevier
The biomedical literature on the subject of neurotrophic growth factors has expanded
prodigiously. This essay reviews neurotrophic factors (NTF) and their receptors in …
prodigiously. This essay reviews neurotrophic factors (NTF) and their receptors in …
The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors
SD Skaper - CNS & Neurological Disorders-Drug Targets …, 2008 - ingentaconnect.com
The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons, and have since been shown to control a …
factors for sympathetic and sensory neurons, and have since been shown to control a …
A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease
MS Rafii, TL Baumann, RAE Bakay, JM Ostrove… - Alzheimer's & …, 2014 - Elsevier
Background Nerve growth factor (NGF) is an endogenous neurotrophic-factor protein with
the potential to restore function and to protect degenerating cholinergic neurons in …
the potential to restore function and to protect degenerating cholinergic neurons in …
Postmortem analysis in a clinical trial of AAV2-NGF gene therapy for Alzheimer's disease identifies a need for improved vector delivery
Nerve growth factor (NGF) gene therapy rescues and stimulates cholinergic neurons, which
degenerate in Alzheimer's disease (AD). In a recent clinical trial for AD, intraparenchymal …
degenerate in Alzheimer's disease (AD). In a recent clinical trial for AD, intraparenchymal …
Gene therapy approach with an emphasis on growth factors: theoretical and clinical outcomes in neurodegenerative diseases
The etiology of many neurological diseases affecting the central nervous system (CNS) is
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …
NGF is essential for hippocampal plasticity and learning
Nerve growth factor (NGF) is produced in the hippocampus throughout life and is
retrogradely trafficked to septal cholinergic neurons, providing a potential mechanism for …
retrogradely trafficked to septal cholinergic neurons, providing a potential mechanism for …