Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Both type 1 and type 2 diabetes have been associated with reduced performance on
multiple domains of cognitive function and with structural abnormalities in the brain. With an …

Diabetes and insulin resistance are associated with altered brain imaging, depression, and
increased rates of age-related cognitive impairment. Here we demonstrate that mice with a …

Despite intensive research efforts over the past few decades, the mechanisms underlying
the etiology of sporadic Alzheimer's disease (AD) remain unknown. This fact is of major …

Annexin A1 (ANXA1) has long been classed as an anti-inflammatory protein due to its
control over leukocyte-mediated immune responses. However, it is now recognized that …

The structure and integrity of the ageing brain is interchangeably linked to physical health,
and cardiometabolic risk factors (CMRs) are associated with dementia and other brain …

Type 2 diabetes mellitus (T2DM) alters brain function and manifests as brain atrophy.
Intranasal insulin has emerged as a promising intervention for treatment of cognitive …

There is increasing interest in factors that may modulate white matter (WM) breakdown and,
consequentially, age-related cognitive and behavioral deficits. Recent diffusion tensor …

Abstract Type 2 Diabetes (T2DM) is emerging as a major global health issue. T2DM can
adversely affect cognition and increase dementia risk. This systematic review aimed to …

Metabolic syndrome is a cluster of cardiovascular risk factors defined by the presence of
abdominal obesity, glucose intolerance, hypertension and/or dyslipidemia. It is a major …