Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
Amyloid cross-seeding: Mechanism, implication, and inhibition
Most neurodegenerative diseases such as Alzheimer's disease, type 2 diabetes, Parkinson's
disease, etc. are caused by inclusions and plaques containing misfolded protein …
disease, etc. are caused by inclusions and plaques containing misfolded protein …
Genistein: a dual inhibitor of both amyloid β and human islet amylin peptides
Abnormal misfolding and aggregation of amyloid peptides into amyloid fibrils are common
and critical pathological events in many neurodegenerative diseases. Most inhibitors or …
and critical pathological events in many neurodegenerative diseases. Most inhibitors or …
Exploration of isoquinoline alkaloids as potential inhibitors against human islet amyloid polypeptide
Y Wang, T Zheng, Y Huo, W Du - ACS Chemical Neuroscience, 2022 - ACS Publications
Type-2 diabetes mellitus (T2DM) is one of the most concerning public health problems
because of its high incidence, multiple complications, and difficult treatment. Human islet …
because of its high incidence, multiple complications, and difficult treatment. Human islet …
Design principles and fundamental understanding of biosensors for amyloid-β detection
Alzheimer's disease (AD), as an age-related, progressive neurodegenerative disease,
poses substantial challenges and burdens on public health and disease research. While …
poses substantial challenges and burdens on public health and disease research. While …
Hydroxylated Single-Walled Carbon Nanotubes Inhibit Aβ42 Fibrillogenesis, Disaggregate Mature Fibrils, and Protect against Aβ42-Induced Cytotoxicity
The fibrillogenesis of amyloid-β protein (Aβ) is considered a crucial factor in the
pathogenesis of Alzheimer's disease (AD). Hence, inhibiting Aβ fibrillogenesis is regarded …
pathogenesis of Alzheimer's disease (AD). Hence, inhibiting Aβ fibrillogenesis is regarded …
From small molecules to synthesized polymers: potential role in combating amyloidogenic disorders
The concept of develo** novel anti-amyloid inhibitors in the scientific community has
engrossed remarkable research interests and embraced significant potential to resolve …
engrossed remarkable research interests and embraced significant potential to resolve …
α-Synuclein: an all-inclusive trip around its structure, influencing factors and applied techniques
N Bisi, L Feni, K Peqini, H Pérez-Peña, S Ongeri… - Frontiers in …, 2021 - frontiersin.org
Alpha-synuclein (αSyn) is a highly expressed and conserved protein, typically found in the
presynaptic terminals of neurons. The misfolding and aggregation of αSyn into amyloid …
presynaptic terminals of neurons. The misfolding and aggregation of αSyn into amyloid …
Enhanced electrochemical performance in microbial fuel cell with carbon nanotube/NiCoAl-layered double hydroxide nanosheets as air-cathode
J Chen, L Jiang, J Yang, X Wang, Y An, D Yang… - International Journal of …, 2021 - Elsevier
The ternary component NiCoAl-layered double hydroxide (NiCoAl-LDH) and carbon
nanotube (CNT) nano-composite (CNT/NiCoAl-LDH) were successfully prepared by a …
nanotube (CNT) nano-composite (CNT/NiCoAl-LDH) were successfully prepared by a …
Amyloid Disassembly: What Can We Learn from Chaperones?
Protein aggregation and subsequent accumulation of insoluble amyloid fibrils with cross-β
structure is an intrinsic characteristic of amyloid diseases, ie, amyloidoses. Amyloid …
structure is an intrinsic characteristic of amyloid diseases, ie, amyloidoses. Amyloid …