Improving immunotherapy efficacy in soft-tissue sarcomas: a biomarker driven and histotype tailored review

M Roulleaux Dugage, EF Nassif, A Italiano… - Frontiers in …, 2021 - frontiersin.org
Anti-PD-(L) 1 therapies yield a disappointing response rate of 15% across soft-tissue
sarcomas, even if some subtypes benefit more than others. The proportions of TAMs and …

[HTML][HTML] Immune cells in the tumor microenvironment of soft tissue sarcomas

E Jumaniyazova, A Lokhonina, D Dzhalilova… - Cancers, 2023 - mdpi.com
Simple Summary Soft tissue sarcomas represent a large heterogeneous group of malignant
neoplasms that are characterized by a poor disease outcome and being poorly studied …

Immune, metabolic landscapes of prognostic signatures for lung adenocarcinoma based on a novel deep learning framework

S Qin, S Sun, Y Wang, C Li, L Fu, M Wu, J Yan, W Li… - Scientific Reports, 2024 - nature.com
Lung adenocarcinoma (LUAD) is a malignant tumor with high lethality, and the aim of this
study was to identify promising biomarkers for LUAD. Using the TCGA-LUAD dataset as a …

[HTML][HTML] Molecular determinants of soft tissue sarcoma immunity: targets for immune intervention

M Tazzari, L Bergamaschi, A De Vita, P Collini… - International Journal of …, 2021 - mdpi.com
Soft tissue sarcomas (STSs) are a family of rare malignant tumors encompassing more than
80 histologies. Current therapies for metastatic STS, a condition that affects roughly half of …

Immunotherapy in sarcoma: where do things stand?

CM Tellez, Y Leyfman, SP D'Angelo… - Surgical Oncology …, 2022 - surgonc.theclinics.com
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Immunologic constant of rejection signature is prognostic in soft-tissue sarcoma and refines the CINSARC signature

F Bertucci, V Niziers, A de Nonneville… - Journal for …, 2022 - pmc.ncbi.nlm.nih.gov
Background Soft-tissue sarcomas (STSs) are heterogeneous and aggressive tumors, with
high metastatic risk. The immunologic constant of rejection (ICR) 20-gene signature is a …

[HTML][HTML] Tumor and peripheral immune status in soft tissue sarcoma: implications for immunotherapy

LM Sousa, JS Almeida, T Fortes-Andrade… - Cancers, 2021 - mdpi.com
Simple Summary Soft Tissue Sarcomas are a rare and heterogeneous group of tumors,
which have a characteristic complexity, leading to a difficult diagnosis and a lack of …

Leveraging a disulfidptosis‑related lncRNAs signature for predicting the prognosis and immunotherapy of glioma

D Chen, Q Li, Y Xu, Y Wei, J Li, X Zhu, H Li, Y Lu… - Cancer Cell …, 2023 - Springer
Background Gliomas, a prevalent form of primary brain tumors, are linked with a high
mortality rate and unfavorable prognoses. Disulfidptosis, an innovative form of programmed …

Identification of the potential regulatory interactions in rheumatoid arthritis through a comprehensive analysis of lncRNA-related ceRNA networks

M Yang, Y Su, H Zheng, K Xu, Q Yuan, Y Cai… - BMC musculoskeletal …, 2023 - Springer
Objective This study aimed at constructing a network of competing endogenous RNA
(ceRNA) in the synovial tissues of rheumatoid arthritis (RA). It seeks to discern potential …

Emerging mechanisms of immunotherapy resistance in sarcomas

V Florou, BA Wilky - Cancer Drug Resistance, 2022 - pmc.ncbi.nlm.nih.gov
Sarcomas are a heterogeneous group of over 150 mesenchymal neoplasms of bone and
soft tissue. Clinical prognosis remains poor in the metastatic and refractory setting, despite …