Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …

To what extent is the convergent evolution of protein function attributable to convergent or
parallel changes at the amino acid level? The mutations that contribute to adaptive protein …

To investigate the predictability of genetic adaptation, we examined the molecular basis of
convergence in hemoglobin function in comparisons involving 56 avian taxa that have …

The protein frustratometer is an energy landscape theory-inspired algorithm that aims at
localizing and quantifying the energetic frustration present in protein molecules. Frustration …

Evolution generates a remarkable breadth of living forms, but many traits evolve repeatedly,
by mechanisms that are still poorly understood. A classic example of repeated evolution is …

Population genomic analyses of high-altitude humans and other vertebrates have identified
numerous candidate genes for hypoxia adaptation, and the physiological pathways …

To cope with the reduced availability of O2 at high altitude, air-breathing vertebrates have
evolved myriad adjustments in the cardiorespiratory system to match tissue O2 delivery with …

In air-breathing vertebrates at high altitude, fine-tuned adjustments in hemoglobin (Hb)–O2
affinity provide an energetically efficient means of mitigating the effects of arterial …

Predicting evolutionary outcomes is an important research goal in a diversity of contexts.
The focus of evolutionary forecasting is usually on adaptive processes, and efforts to …

The primary aim of this book is to provide a synthesis of our current understanding of
hemoglobin function and evolution, and to illustrate how research on one particular family of …