Within less than a decade since its inception, CRISPR-Cas9-based genome editing has
been rapidly advanced to human clinical trials in multiple disease areas. Although it is highly …

There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

The endoplasmic reticulum (ER) as an intracellular Ca2+ store not only sets up cytosolic
Ca2+ signals, but, among other functions, also assembles and folds newly synthesized …

Contractile motion is the simplest metric of cardiomyocyte health in vitro, but unbiased
quantification is challenging. We describe a rapid automated method, requiring only …

Well over 2 decades have passed since the endothelium-derived relaxation factor was
reported to be the gaseous molecule nitric oxide (NO). Although soluble guanylyl cyclase …

Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated
cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart …

The heart responds to injury and chronic pressure overload by pathologic growth and
remodeling, which frequently result in heart failure and sudden death. Calcium-dependent …

Atrial fibrillation (AF), the most common human cardiac arrhythmia, is associated with
abnormal intracellular Ca2+ handling. Diastolic Ca2+ release from the sarcoplasmic …

Ca is critical in both the electrical and mechanical properties of cardiac myocytes, and much
is known about ionic currents and the normal excitation-contraction coupling process. In …

Abnormal cardiac ryanodine receptor (RyR2) function is recognized as an important factor in
the pathogenesis of heart failure (HF). However, the specific molecular causes underlying …