The hybridization of heterocycles presents a key opportunity to craft innovative multicyclic
compounds with enhanced biological activity. Coumarins, being broadly prevalent natural …

Infectious diseases resulting from various strains of pathogenic bacteria are among the
leading causes of death and morbidity worldwide. The currently-available antibacterial …

Since 1947, a sterically hindered phenol named 3-(tert-butyl)-4-methoxyphenol, abbreviated
here as 3-tBMP, has been widely used as a powerful preservative antioxidant for food …

Abstract 3, 4, 5-Trimethoxy-3′-hydroxy-4′-methoxystilbene (TMHMS) is an anticancer
natural stilbene that targets tubulin polymerization. According to research, oxidative stress …

Background Resveratrol (RVL) is a polyphenol-containing natural product found in a variety
of plants, including peanuts, grapes, and berry fruits. The use of RVL is linked in a great deal …

Fluorouracil (5-FU) has been commonly used as a chemotherapy medication in cancer
management. However, owing to its substantial side effects, limited selectivity, and tumor …

A potent natural combretastatin, combretastatin A-4 (COMA4) targets the condylon active
pocket to produce anticancer effects. Studies on inflammation and oxidative stress have …

In an attempt to find versatile and readily accessible coumarin scaffolds with a broad
spectrum of biomedical properties, seven bisimidazole–coumarin conjugates were …

Many efforts have been directed toward the isolation of natural products, and using them to
synthesize new chemical agents, and explore their cytotoxic attributes. However, finding …

The oral administration of the standard cytotoxic agent 5-fluorouracil is extensively limited in
the last three decades. This restriction is due to the drug's uneven intestinal absorption due …