Thymidine phosphorylase: A potential new target for treating cardiovascular disease

W Li, H Yue - Trends in cardiovascular medicine, 2018‏ - Elsevier
We recently found that thymidine phosphorylase (TYMP), also known as platelet-derived
endothelial cell growth factor, plays an important role in platelet activation in vitro and …

A phase II study of biweekly paclitaxel and cisplatin chemotherapy for recurrent or metastatic esophageal squamous cell carcinoma: ERCC1 expression predicts …

J Huang, Y Zhou, H Zhang, T Qu, Y Mao, H Zhu… - Medical oncology, 2013‏ - Springer
Recurrent or metastatic esophageal cancer has poor prognosis. This study was to assess
the efficacy and safety of biweekly paclitaxel and cisplatin combination for patients with …

Quantification and expert evaluation of evidence for chemopredictive biomarkers to personalize cancer treatment

S Rao, RA Beckman, S Riazi, CS Yabar, SM Boca… - …, 2016‏ - pmc.ncbi.nlm.nih.gov
Predictive biomarkers have the potential to facilitate cancer precision medicine by guiding
the optimal choice of therapies for patients. However, clinicians are faced with an enormous …

Nanoparticle albumin-bound paclitaxel combined with cisplatin as the first-line treatment for metastatic esophageal squamous cell carcinoma

Y Shi, R Qin, ZK Wang, GH Dai - OncoTargets and therapy, 2013‏ - Taylor & Francis
Esophageal cancer is a major health hazard in many parts of the world and is often
diagnosed late. The objective of this study was to explore the efficacy and safety of …

Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?

ME Valsecchi, T Holdbrook, BE Leiby, E Pequignot… - BMC cancer, 2012‏ - Springer
Background RRM1 and ERCC1 overexpression has been extensively investigated as
potential predictive markers of tumor sensitivity to conventional chemotherapy agents, most …

Thymidylate synthase expression is closely associated with outcome in patients with pulmonary adenocarcinoma

K Kaira, Y Ohde, K Nakagawa, T Okumura… - Medical Oncology, 2012‏ - Springer
The aim of this study is to elucidate the prognostic significance of thymidylate synthase (TS),
orotate phosphoribosyltransferase (OPRT) and dihydropyrimidine dehydrogenase (DPD) in …

Serum levels of TUBB3 correlate with clinical outcome in Chinese patients with advanced gastric cancer receiving first-line paclitaxel plus capecitabine

J Yu, J Gao, Z Lu, Y Li, L Shen - Medical Oncology, 2012‏ - Springer
The overexpression of β-tubulin III (TUBB3) in tumor tissues was reversely related with the
efficacy of paclitaxel and clinical outcome in different cancers. In this study, we aimed to …

Metformin Induces Cytotoxicity by Down‐Regulating Thymidine Phosphorylase and Excision Repair Cross‐Complementation 1 Expression in Non‐Small Cell Lung …

JC Ko, YC Huang, HJ Chen, SC Tseng… - Basic & clinical …, 2013‏ - Wiley Online Library
Metformin is an antidiabetic drug recently shown to inhibit cancer cell proliferation and
growth, although the involved molecular mechanisms have not been elucidated. In many …

Systemic therapy for metastatic or recurrent squamous cell carcinoma of the head and neck

AD Colevas - Journal of the National Comprehensive Cancer …, 2015‏ - jnccn.org
This article summarizes the systemic treatment options for patients with recurrent and/or
metastatic squamous cell carcinoma of the head and neck, with an emphasis on …

Capecitabine with/without mitomycin C: results of a randomized phase II trial of second-line therapy in advanced biliary tract adenocarcinoma

S Cereda, M Milella, S Cordio, F Leone… - Cancer chemotherapy …, 2016‏ - Springer
Purpose Advanced biliary tract adenocarcinoma (BTA) is a rare tumor with a poor prognosis.
Since no standard salvage chemotherapy regimen exists, we explored the activity of …