Abstract Real-world evidence (RWE), the understanding of treatment effectiveness in clinical
practice generated from longitudinal patient-level data from the routine operation of the …

The analysis of longitudinal healthcare data outside of highly controlled parallel‐group
randomized trials, termed real‐world evidence (RWE), has received increasing attention in …

Importance Nonrandomized studies using insurance claims databases can be analyzed to
produce real-world evidence on the effectiveness of medical products. Given the lack of …

In pharmacoepidemiology, routinely collected data from electronic health records (including
primary care databases, registries, and administrative healthcare claims) are a resource for …

Importance SARS-CoV-2, which causes COVID-19, poses considerable morbidity and
mortality risks. Studies using data collected during routine clinical practice can supplement …

Here we identify hundreds of new drug-disease associations for over 900 FDA-approved
drugs by quantifying the network proximity of disease genes and drug targets in the human …

Studies that generate real-world evidence on the effects of medical products through
analysis of digital data collected in clinical practice provide key insights for regulators …

In alignment with the International Council of Harmonization's strategic goals, a public-
private consortium has developed a structured template for planning and reporting on the …

Background: Regulators are evaluating the use of noninterventional real-world evidence
(RWE) studies to assess the effectiveness of medical products. The RCT DUPLICATE …

Risk of Diabetic Ketoacidosis after Initiation of an SGLT2 Inhibitor Page 1 Correspondence The
new england journal of medicine n engl j med 376;23 nejm.org June 8, 2017 2300 …