Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease
Cutaneous mast cells (MCs) express Mas-related G protein–coupled receptor-X2
(MRGPRX2; mouse ortholog MrgprB2), which is activated by an ever-increasing number of …
(MRGPRX2; mouse ortholog MrgprB2), which is activated by an ever-increasing number of …
G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions and inflammation
H Cheng, P Guo, T Su, C Jiang, Z Zhu, W Wei, L Zhang… - Cellular …, 2022 - Elsevier
G protein-coupled receptor kinase type 2 (GRK2) and β-arrestin2 are representative proteins
that regulate the transduction and trafficking of G protein-coupled receptor (GPCR) …
that regulate the transduction and trafficking of G protein-coupled receptor (GPCR) …
The pseudoallergen receptor MRGPRX2 on peripheral blood basophils and eosinophils: Expression and function
Background Mas‐related G protein‐coupled receptor X2 (MRGPRX2) is regarded as a mast
cell‐specific receptor mediating non–IgE‐dependent activation. We aimed to investigate …
cell‐specific receptor mediating non–IgE‐dependent activation. We aimed to investigate …
Inhibition of MRGPRX2 but not FcεRI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist
Mas-related G protein-coupled receptor-X2 (MRGPRX2) expressed on mast cells (MCs)
contributes to hypersensitivity reactions to cationic US-Food and Drug Administration (FDA) …
contributes to hypersensitivity reactions to cationic US-Food and Drug Administration (FDA) …
[HTML][HTML] MRGPRX2 is the codeine receptor of human skin mast cells: desensitization through β-arrestin and lack of correlation with the FcεRI pathway
M Babina, Z Wang, S Roy, S Guhl, K Franke… - Journal of Investigative …, 2021 - Elsevier
Codeine stimulates skin mast cells and is therefore used in skin tests and as an inducer of
experimental itch. MRGPRX2 responds to various drugs, including opioids, to elicit …
experimental itch. MRGPRX2 responds to various drugs, including opioids, to elicit …
Osthole, a natural plant derivative inhibits MRGPRX2 induced mast cell responses
BN Callahan, AK Kammala, M Syed, C Yang… - Frontiers in …, 2020 - frontiersin.org
Mast cells are tissue-resident innate immune cells known for their prominent role in
mediating allergic reactions. MAS-related G-protein coupled receptor-X2 (MRGPRX2) is a …
mediating allergic reactions. MAS-related G-protein coupled receptor-X2 (MRGPRX2) is a …
MRGPRX2-Mediated Degranulation of Human Skin Mast Cells Requires the Operation of Gαi, Gαq, Ca++ Channels, ERK1/2 and PI3K—Interconnection between …
The recent discovery of MRGPRX2 explains mast cell (MC)-dependent symptoms
independently of FcεRI-activation. Because of its novelty, signaling cascades triggered by …
independently of FcεRI-activation. Because of its novelty, signaling cascades triggered by …
Mast cell MrgprB2 in neuroimmune interaction in IgE-mediated airway inflammation and its modulation by β-arrestin2
Introduction Allergic asthma has been linked to the activation of mast cells (MCs) by the
neuropeptide substance P (SP), but the mechanism underlying this neuroimmune …
neuropeptide substance P (SP), but the mechanism underlying this neuroimmune …
Inhibition of orai channel function regulates mas-related G protein-coupled receptor-mediated responses in mast cells
Mast cells (MCs) are tissue resident immune cells that play important roles in the
pathogenesis of allergic disorders. These responses are mediated via the cross-linking of …
pathogenesis of allergic disorders. These responses are mediated via the cross-linking of …
β-arrestin-1 and β-arrestin-2 restrain MRGPRX2-triggered degranulation and ERK1/2 activation in human skin mast cells
As a novel receptor that efficiently elicits degranulation upon binding to one of its numerous
ligands, MRGPRX2 has moved to the center of attention in mast cell (MC) research. Indeed …
ligands, MRGPRX2 has moved to the center of attention in mast cell (MC) research. Indeed …