Next-generation sequencing (NGS) technology has expanded in the last decades with
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …

Recent advances in genome sequencing technologies provide unprecedented opportunities
to characterize individual genomic landscapes and identify mutations relevant for diagnosis …

Importance Estimates of familial cancer risk from population-based studies are essential
components of cancer risk prediction. Objective To estimate familial risk and heritability of …

Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …

Most common breast cancer susceptibility variants have been identified through genome-
wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease …

Genome-wide association studies (GWAS) and large-scale replication studies have
identified common variants in 79 loci associated with breast cancer, explaining∼ 14% of the …

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations,
confer clonal selective advantage on cancer cells and are causally implicated in …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …

EDITOR-IN-CHIEF: Clifford J. Rosen, MD, Maine Medical Center Research Institute,
Scarborough, Maine SENIOR ASSOCIATE EDITORS: Juliet E. Compston, MD, FRCP …

The translation of basic research into improved therapies for breast cancer patients requires
relevant preclinical models that incorporate spontaneous metastasis. We have completed a …