Human neuronal maturation comes of age: cellular mechanisms and species differences
The delayed and prolonged postmitotic maturation of human neurons, compared with
neurons from other species, may contribute to human-specific cognitive abilities and …
neurons from other species, may contribute to human-specific cognitive abilities and …
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
Abstract Canonical (H3. 1/H3. 2) and noncanonical (H3. 3) histone 3 K27M-mutant gliomas
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
Glial modulation of synapse development and plasticity: Oligodendrocyte precursor cells as a new player in the synaptic quintet
YO Akinlaja, A Nishiyama - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
Synaptic communication is an important process in the central nervous system that allows
for the rapid and spatially specified transfer of signals. Neurons receive various synaptic …
for the rapid and spatially specified transfer of signals. Neurons receive various synaptic …
Spatio-temporal dynamics enhance cellular diversity, neuronal function and further maturation of human cerebral organoids
P Saglam-Metiner, U Devamoglu, Y Filiz… - Communications …, 2023 - nature.com
The bioengineerined and whole matured human brain organoids stand as highly valuable
three-dimensional in vitro brain-mimetic models to recapitulate in vivo brain development …
three-dimensional in vitro brain-mimetic models to recapitulate in vivo brain development …
DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice
G Huang, Z Li, X Liu, M Guan, S Zhou, X Zhong… - Nature …, 2024 - nature.com
The decreased ability of mature oligodendrocytes to produce myelin negatively affects
remyelination in demyelinating diseases and aging, but the underlying mechanisms are …
remyelination in demyelinating diseases and aging, but the underlying mechanisms are …
Alterations of oligodendrocyte and myelin energy metabolism in multiple sclerosis
E López-Muguruza, C Matute - International journal of molecular sciences, 2023 - mdpi.com
Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system
(CNS), characterized by demyelination and neurodegeneration. Oligodendrocytes play a …
(CNS), characterized by demyelination and neurodegeneration. Oligodendrocytes play a …
Novel in vitro Experimental Approaches to Study Myelination and Remyelination in the Central Nervous System
Myelin is the lipidic insulating structure enwrap** axons and allowing fast saltatory nerve
conduction. In the central nervous system, myelin sheath is the result of the complex …
conduction. In the central nervous system, myelin sheath is the result of the complex …
Presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelination
CD Fekete, A Nishiyama - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Myelination is critical for fast saltatory conduction of action potentials. Recent studies have
revealed that myelin is not a static structure as previously considered but continues to be …
revealed that myelin is not a static structure as previously considered but continues to be …
Sha** of regional differences in oligodendrocyte dynamics by regional heterogeneity of the pericellular microenvironment
Oligodendrocyte precursor cells (OPCs) are glial cells that differentiate into mature
oligodendrocytes (OLs) to generate new myelin sheaths. While OPCs are distributed …
oligodendrocytes (OLs) to generate new myelin sheaths. While OPCs are distributed …
Activity-dependent oligodendrocyte calcium dynamics and their changes in Alzheimer's disease
K Yoshida, D Kato, S Sugio, I Takeda… - Frontiers in Cellular …, 2023 - frontiersin.org
Oligodendrocytes (OCs) form myelin around axons, which is dependent on neuronal activity.
This activity-dependent myelination plays a crucial role in training and learning. Previous …
This activity-dependent myelination plays a crucial role in training and learning. Previous …