Emerging phagocytosis checkpoints in cancer immunotherapy
Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …
Phagocytosis checkpoints as new targets for cancer immunotherapy
Cancer immunotherapies targeting adaptive immune checkpoints have substantially
improved patient outcomes across multiple metastatic and treatment-refractory cancer types …
improved patient outcomes across multiple metastatic and treatment-refractory cancer types …
Chemotherapeutic drug-induced immunogenic cell death for nanomedicine-based cancer chemo–immunotherapy
M Jiang, J Zeng, L Zhao, M Zhang, J Ma, X Guan… - Nanoscale, 2021 - pubs.rsc.org
Chemotherapy has been a conventional paradigm for cancer treatment, and multifarious
chemotherapeutic drugs have been widely employed for decades with significant …
chemotherapeutic drugs have been widely employed for decades with significant …
[PDF][PDF] Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte
SJ Gardai, KA McPhillips, SC Frasch, WJ Janssen… - Cell, 2005 - cell.com
Apoptotic-cell removal is critical for development, tissue homeostasis, and resolution of
inflammation. Although many candidate systems exist, only phosphatidylserine has been …
inflammation. Although many candidate systems exist, only phosphatidylserine has been …
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
RJ Kaufman - Genes & development, 1999 - genesdev.cshlp.org
All eukaryotic cells have an extensive membranous labyrinth network of branching tubules
and flattened sacs called the endoplasmic reticulum (ER). Approximately one-third of all …
and flattened sacs called the endoplasmic reticulum (ER). Approximately one-third of all …
The nuclear vitamin D receptor: biological and molecular regulatory properties revealed
IN THE DECADE SINCE THE VITAMIN Dreceptor (VDR) was cloned (1) and recognized as
a member of the superfamily of nuclear receptors that regulate gene expression in a ligand …
a member of the superfamily of nuclear receptors that regulate gene expression in a ligand …
Chaperone-mediated protein folding
AL Fink - Physiological reviews, 1999 - journals.physiology.org
The folding of most newly synthesized proteins in the cell requires the interaction of a variety
of protein cofactors known as molecular chaperones. These molecules recognize and bind …
of protein cofactors known as molecular chaperones. These molecules recognize and bind …
Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum
Calreticulin is an ER (endoplasmic reticulum) luminal Ca2+-buffering chaperone. The
protein is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity …
protein is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity …
Calreticulin: one protein, one gene, many functions
M Michalak, EF CORBETT, N MESAELI… - Biochemical …, 1999 - portlandpress.com
The endoplasmic reticulum (ER) plays a critical role in the synthesis and chaperoning of
membrane-associated and secreted proteins. The membrane is also an important site of …
membrane-associated and secreted proteins. The membrane is also an important site of …
Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress
In contrast to other cytotoxic agents including anthracyclins and oxaliplatin (OXP), cisplatin
(CDDP) fails to induce immunogenic tumor cell death that would allow to stimulate an …
(CDDP) fails to induce immunogenic tumor cell death that would allow to stimulate an …