In the 12 years since the process of RNA interference (RNAi) was first discovered, great
progress has been made in understanding its mechanism and exploiting its ability to silence …

Nucleic acid-based therapeutic molecules including small interfering RNA (siRNA),
microRNA (miRNA), antisense oligonucleotides (ASOs), messenger RNA (mRNA), and DNA …

RNAi is a potent technique for the knockdown of target genes. However, its potential off-
target effects limit the widespread applications in both reverse genetic analysis and genetic …

Viral RNA-host protein interactions are critical for replication of flaviviruses, a genus of
positive-strand RNA viruses comprising major vector-borne human pathogens including …

Chitosan (CS) shows in vitro and in vivo efficacy for siRNA delivery but with contradictory
findings for incompletely characterized systems. For understanding which parameters …

Because off-target effects hamper interpretation and validation of RNAi screen data, we
developed a bioinformatics method, genome-wide enrichment of seed sequence matches …

Small interfering RNAs (siRNAs) are now established as the preferred tool to inhibit gene
function in mammalian cells yet trigger unintended gene silencing due to their inherent …

Small interfering RNA (siRNA)-based therapies have great promise in the treatment of a
number of prevalent pulmonary disorders including lung cancer, asthma and cystic fibrosis …

The intracellular signals that convert fast and slow motor neuron activity into muscle fiber
type specific transcriptional programs have only been partially defined. The …

Chitosan has gained increasing interest for siRNA delivery. Although chitosan covers a
family of structurally different polysaccharides, most siRNA delivery studies have been …