Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications—risks and mitigation

M Kropp, O Golubnitschaja, A Mazurakova… - Epma Journal, 2023 - Springer
Proliferative diabetic retinopathy (PDR) the sequel of diabetic retinopathy (DR), a frequent
complication of diabetes mellitus (DM), is the leading cause of blindness in the working-age …

Oxidative stress in diabetes: implications for vascular and other complications

D Pitocco, M Tesauro, R Alessandro… - International journal of …, 2013 - mdpi.com
In recent decades, oxidative stress has become a focus of interest in most biomedical
disciplines and many types of clinical research. Increasing evidence shows that oxidative …

Nutraceuticals for the treatment of diabetic retinopathy

MG Rossino, G Casini - Nutrients, 2019 - mdpi.com
Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus and
is characterized by degeneration of retinal neurons and neoangiogenesis, causing a severe …

Flavonoid naringenin attenuates oxidative stress, apoptosis and improves neurotrophic effects in the diabetic rat retina

DI Al-Dosari, MM Ahmed, SS Al-Rejaie, AS Alhomida… - Nutrients, 2017 - mdpi.com
Diabetic retinopathy (DR) is one of the leading causes of decreased vision and blindness
worldwide. Diabetes-induced oxidative stress is believed to be the key factor that initiates …

Roles of miRNAs and long noncoding RNAs in the progression of diabetic retinopathy

Q Gong, G Su - Bioscience Reports, 2017 - portlandpress.com
Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults across the
world. The pathogenesis of DR is multifactorial and the molecular mechanisms are still not …

Role of microRNAs in the modulation of diabetic retinopathy

R Mastropasqua, L Toto, F Cipollone… - Progress in Retinal and …, 2014 - Elsevier
Diabetic retinopathy (DR) is the leading cause of vision loss in the working-age adults. It
affects a third of diabetics. Diabetic macular edema, an advanced complication of DR …

Diabetic retinopathy–biomolecules and multiple pathophysiology

H Ahsan - Diabetes & Metabolic Syndrome: Clinical Research & …, 2015 - Elsevier
One of the major complications in patients with diabetes is diabetic retinopathy (DR), a
leading cause of blindness worldwide. It causes visual impairment and finally blindness, a …

Neuroprotective effects of rutin in streptozotocin-induced diabetic rat retina

MS Ola, MM Ahmed, R Ahmad… - Journal of Molecular …, 2015 - Springer
Diabetic retinopathy is widely recognized as a neurodegenerative disease of the eye.
Increased oxidative stress has been considered the central factor in damaging neural retina …

Long non‐coding RNA MALAT 1 regulates retinal neurodegeneration through CREB signaling

J Yao, XQ Wang, YJ Li, K Shan, H Yang… - EMBO molecular …, 2016 - embopress.org
The nervous and vascular systems, although functionally different, share many common
regulators of function maintenance. Long non‐coding RNA s (lnc RNA s) are important …

Noncoding RNAs involved in DNA methylation and histone methylation, and acetylation in diabetic vascular complications

J Lu, Y Huang, X Zhang, Y Xu, S Nie - Pharmacological Research, 2021 - Elsevier
Diabetes is a metabolic disorder and its incidence is still increasing. Diabetic vascular
complications cause major diabetic mobility and include accelerated atherosclerosis …