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[HTML][HTML] Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …
[HTML][HTML] Immunomodulatory role of the extracellular matrix within the liver disease microenvironment
CE McQuitty, R Williams, S Chokshi… - Frontiers in …, 2020 - frontiersin.org
Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …
Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids
Matrigel, a mouse tumor extracellular matrix protein mixture, is an indispensable component
of most organoid tissue culture. However, it has limited the utility of organoids for drug …
of most organoid tissue culture. However, it has limited the utility of organoids for drug …
Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in …
It is believed that mucoadhesive surface properties on particles delivered to the
gastrointestinal (GI) tract improve oral absorption or local targeting of various difficult-to …
gastrointestinal (GI) tract improve oral absorption or local targeting of various difficult-to …
Regulation of tumor immunity and immunotherapy by the tumor collagen extracellular matrix
It has been known for decades that the tumor extracellular matrix (ECM) is dysfunctional
leading to loss of tissue architecture and promotion of tumor growth. The altered ECM and …
leading to loss of tissue architecture and promotion of tumor growth. The altered ECM and …
Biological interplay between proteoglycans and their innate immune receptors in inflammation
An emerging body of evidence indicates that secreted proteoglycans act as signaling
molecules, in addition to their canonical function in maintaining and regulating the …
molecules, in addition to their canonical function in maintaining and regulating the …
Intestinal mucus barrier: a missing piece of the puzzle in food allergy
The prevalence of food allergies has reached epidemic levels but the cause remains largely
unknown. We discuss the clinical relevance of the gut mucosal barrier as a site for allergic …
unknown. We discuss the clinical relevance of the gut mucosal barrier as a site for allergic …
TNF-α–stimulated fibroblasts secrete lumican to promote fibrocyte differentiation
In healing wounds and fibrotic lesions, fibroblasts and monocyte-derived fibroblast-like cells
called fibrocytes help to form scar tissue. Although fibrocytes promote collagen production …
called fibrocytes help to form scar tissue. Although fibrocytes promote collagen production …
Distribution and function of glycosaminoglycans and proteoglycans in the development, homeostasis and pathology of the ocular surface
The ocular surface, which forms the interface between the eye and the external environment,
includes the cornea, corneoscleral limbus, the conjunctiva and the accessory glands that …
includes the cornea, corneoscleral limbus, the conjunctiva and the accessory glands that …
Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation
Inflammation is not only a defensive mechanism against microbial invasion, but also
frequently represents a critical response to tissue injury under sterile conditions. It is now …
frequently represents a critical response to tissue injury under sterile conditions. It is now …