Bone diseases/injuries have been driving an urgent quest for bone substitutes for bone
regeneration. Nanoscaled materials with bone-mimicking characteristics may create suitable …

Bone quality is determined by a variety of compositional, micro-and ultrastructural properties
of the mineralized tissue matrix. In contrast to X-ray-based methods, the interaction of …

We investigate the three-dimensional (3-D) organization of mineralized collagen fibrils in
human cortical bone based on synchrotron X-ray phase nano-tomography images. In …

Tissue engineering has been a subject of extensive scientific exploration in the last two
decades making gradual inroads into clinical studies as well. Along with regenerative cells …

Tissue level structural and mechanical properties are important determinants of bone
strength. As an individual ages, microstructural changes occur in bone, eg, trabeculae and …

Cortical bone tissue is an anisotropic material characterized by typically five independent
elastic coefficients (for transverse isotropy) governing shear and longitudinal deformations in …

Functional adaptation of the femur has been studied extensively by embedding remodelling
algorithms in finite element models, with bone commonly assumed to have isotropic material …

Alterations of structure and density of cortical bone are associated with fragility fractures and
can be assessed in vivo in humans at the tibia. Bone remodeling deficits in aging women …

Most bone loss during the development of osteoporosis occurs in cortical bone at the
peripheral skeleton. Decreased cortical thickness (Ct. Th) and the prevalence of large pores …

A characteristic relationship for bone between bone volume fraction (BV/TV) and specific
surface (BS/TV) has previously been proposed based on 2D histological measurements …