A long standing problem in structural bioinformatics is to determine the three-dimensional (3-
D) structure of a protein when only a sequence of amino acid residues is given. Many …

During the past 15 years there has been a continuous flow of reports describing proteins
stabilized by the introduction of mutations. These reports span a period from pioneering …

The Rosetta molecular modeling software package provides experimentally tested and
rapidly evolving tools for the 3D structure prediction and high-resolution design of proteins …

Protein–protein recognition plays a central role in most biological processes. Although the
structures of many protein–protein complexes have been solved in molecular detail, general …

Hydrogen bonding is a key contributor to the specificity of intramolecular and intermolecular
interactions in biological systems. Here, we develop an orientation-dependent hydrogen …

Engineering proteins to withstand a broad range of conditions continues to be a coveted
objective, holding the potential to advance biomedicine, industry, and our understanding of …

This review provides an exposition to the important problems of (i) structure prediction in
protein folding and (ii) de novo protein design. The recent advances in protein folding are …

Although protein-folding studies began several decades ago, it is only recently that the tools
to analyze protein folding at the single-molecule level have been developed. Advances in …

We developed a'computational second-site suppressor'strategy to redesign specificity at a
protein-protein interface and applied it to create new specifically interacting DNase-inhibitor …

An increasing number of engineered protein therapeutics are currently being developed,
tested in clinical trials and marketed for use. Many of these proteins arose out of hit-and-miss …