miRNAs as potential game-changers in bone diseases: Future medicinal and clinical Uses
Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …
expression by sequential mechanisms such as mRNA breakdown or translational …
Modulating ROS to overcome multidrug resistance in cancer
The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …
[HTML][HTML] Battling chemoresistance in cancer: root causes and strategies to uproot them
With nearly 10 million deaths, cancer is the leading cause of mortality worldwide. Along with
major key parameters that control cancer treatment management, such as diagnosis …
major key parameters that control cancer treatment management, such as diagnosis …
Chemotherapy and chemo-resistance in nasopharyngeal carcinoma
S Guan, J Wei, L Huang, L Wu - European Journal of Medicinal Chemistry, 2020 - Elsevier
Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) and
occurs frequently in the south of China and Southeast Asian countries. Concurrent chemo …
occurs frequently in the south of China and Southeast Asian countries. Concurrent chemo …
[HTML][HTML] Novel strategies to prevent the development of multidrug resistance (MDR) in cancer
J Wang, N Seebacher, H Shi, Q Kan, Z Duan - Oncotarget, 2017 - ncbi.nlm.nih.gov
The development of multidrug resistance (MDR) is one of the major challenges to the
success of traditional chemotherapy treatment in cancer patients. Most studies to date have …
success of traditional chemotherapy treatment in cancer patients. Most studies to date have …
Anticancer thiosemicarbazones: chemical properties, interaction with iron metabolism, and resistance development
FS PapeVeronika, A EnyedyÉva… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: During the past decades, thiosemicarbazones were clinically developed for a
variety of diseases, including tuberculosis, viral infections, malaria, and cancer. With regard …
variety of diseases, including tuberculosis, viral infections, malaria, and cancer. With regard …
[HTML][HTML] ent-Kaurane diterpenoids induce apoptosis and ferroptosis through targeting redox resetting to overcome cisplatin resistance
Y Sun, Y Qiao, Y Liu, J Zhou, X Wang, H Zheng, Z Xu… - Redox biology, 2021 - Elsevier
Reactive oxygen species (ROS) induction is an effective mechanism to kill cancer cells for
many chemotherapeutics, while resettled redox homeostasis induced by the anticancer …
many chemotherapeutics, while resettled redox homeostasis induced by the anticancer …
Copper complexes as anticancer agents targeting topoisomerases I and II
C Molinaro, A Martoriati, L Pelinski, K Cailliau - Cancers, 2020 - mdpi.com
Simple Summary Organometallics, such as copper compounds, are cancer
chemotherapeutics used alone or in combination with other drugs. One small group of …
chemotherapeutics used alone or in combination with other drugs. One small group of …
Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy
Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …
Antitumor drugs and their targets
Z Dembic - Molecules, 2020 - mdpi.com
Through novel methodologies, including both basic and clinical research, progress has
been made in the therapy of solid cancer. Recent innovations in anticancer therapies …
been made in the therapy of solid cancer. Recent innovations in anticancer therapies …