miRNAs as potential game-changers in bone diseases: Future medicinal and clinical Uses

AS Doghish, MS Elballal, O Elazazy… - … -Research and Practice, 2023 - Elsevier
Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …

Modulating ROS to overcome multidrug resistance in cancer

Q Cui, JQ Wang, YG Assaraf, L Ren, P Gupta… - Drug Resistance …, 2018 - Elsevier
The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

[HTML][HTML] Battling chemoresistance in cancer: root causes and strategies to uproot them

A Ramos, S Sadeghi, H Tabatabaeian - International journal of molecular …, 2021 - mdpi.com
With nearly 10 million deaths, cancer is the leading cause of mortality worldwide. Along with
major key parameters that control cancer treatment management, such as diagnosis …

Chemotherapy and chemo-resistance in nasopharyngeal carcinoma

S Guan, J Wei, L Huang, L Wu - European Journal of Medicinal Chemistry, 2020 - Elsevier
Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) and
occurs frequently in the south of China and Southeast Asian countries. Concurrent chemo …

[HTML][HTML] Novel strategies to prevent the development of multidrug resistance (MDR) in cancer

J Wang, N Seebacher, H Shi, Q Kan, Z Duan - Oncotarget, 2017 - ncbi.nlm.nih.gov
The development of multidrug resistance (MDR) is one of the major challenges to the
success of traditional chemotherapy treatment in cancer patients. Most studies to date have …

Anticancer thiosemicarbazones: chemical properties, interaction with iron metabolism, and resistance development

FS PapeVeronika, A EnyedyÉva… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: During the past decades, thiosemicarbazones were clinically developed for a
variety of diseases, including tuberculosis, viral infections, malaria, and cancer. With regard …

[HTML][HTML] ent-Kaurane diterpenoids induce apoptosis and ferroptosis through targeting redox resetting to overcome cisplatin resistance

Y Sun, Y Qiao, Y Liu, J Zhou, X Wang, H Zheng, Z Xu… - Redox biology, 2021 - Elsevier
Reactive oxygen species (ROS) induction is an effective mechanism to kill cancer cells for
many chemotherapeutics, while resettled redox homeostasis induced by the anticancer …

Copper complexes as anticancer agents targeting topoisomerases I and II

C Molinaro, A Martoriati, L Pelinski, K Cailliau - Cancers, 2020 - mdpi.com
Simple Summary Organometallics, such as copper compounds, are cancer
chemotherapeutics used alone or in combination with other drugs. One small group of …

Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy

KE Arnst, S Banerjee, H Chen, S Deng… - Medicinal research …, 2019 - Wiley Online Library
Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …

Antitumor drugs and their targets

Z Dembic - Molecules, 2020 - mdpi.com
Through novel methodologies, including both basic and clinical research, progress has
been made in the therapy of solid cancer. Recent innovations in anticancer therapies …