The inhibitor of apoptosis (IAP) proteins all contain one or more baculoviral IAP repeat
motifs, through which they interact with various other proteins. Many IAPs also have another …

The spatio-temporal regulation of gene expression determines the fate and function of
various cells and tissues and, as a consequence, the correct development and functioning of …

In many metazoans, damaged and potentially dangerous cells are rapidly eliminated by
apoptosis. In Drosophila, this is often compensated for by extraproliferation of neighboring …

Achieving proper organ size requires a balance between proliferation and cell death. For
example, at least 40%–60% of cells in the Drosophila wing disc can be lost, yet these discs …

Parkinson's disease (PD) is the most common movement disorder characterized by
dopaminergic dysfunction and degeneration. The cause of most PD cases is unknown …

We identified a rhodol bearing a hydroxymethyl group (HMDER) as a suitable scaffold for
designing fluorescence probes for various hydrolases. HMDER shows strong fluorescence …

Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogen-activated protein
kinase kinase kinase family, which activates c-Jun N-terminal kinase and p38 in response to …

Parkin, an E3 ubiquitin ligase, has been found to be responsible for autosomal recessive
juvenile parkinsonism characterized primarily by selective loss of dopaminergic neurons …

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK)
kinase kinase of the c-Jun N-terminal kinase (JNK) and p38 MAPK pathways. ASK1 is …

Tumor necrosis factor receptors (TNFRs) control pleiotropic pro-inflammatory functions that
range from apoptosis to cell survival. The ability to trigger a particular function will depend …