Spiro heterocycle frameworks are a class of organic compounds that possesses unique
structural features making them highly sought-after targets in drug discovery due to their …

Spiro-heterocycles garner much fascination due to their unique conformational features and
vast biological applications than simple heterocycles. The number of spirocyclic scaffolds …

Spiro heterocyclic compounds, particularly those containing the spiropyrrolidine scaffold, are
widely found in numerous natural alkaloids and are recognized for their exceptional …

Background Despite advancements in treatment modalities, the search for new cytotoxic
agents remains vital in the fight against cancer. This ongoing effort aims to introduce novel …

The diazo matrine was synthesized from matrine and then spiro matrine derivatives were
obtained by [3+ 2] cycloaddition reaction with acrylates at room temperature without catalyst …