The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …

As blood–brain barrier (BBB) disruption emerges as a common problem in the early stages
of neurodegenerative diseases, the crucial roles of barrier-type brain endothelial cells …

Alzheimer's disease (AD) is an age-related disease, with loss of integrity of the blood–brain
barrier (BBB) being an early feature. Cellular senescence is one of the reported nine …

Proper functioning of the neural retina relies on the unique retinal environment regulated by
the blood–retinal barrier (BRB), which restricts the passage of solutes, fluids, and toxic …

Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by the
accumulation of amyloid-beta (Aβ), hyperphosphorylation of tau, and neuroinflammation in …

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder with pathological
features of β-amyloid (Aβ) and hyperphosphorylated tau protein accumulation in the brain …

Proper cerebrovascular development and neurogliovascular unit assembly are essential for
brain growth and function throughout life, ensuring the continuous supply of nutrients and …

The blood-brain barrier (BBB) is primarily manifested by a variety of physiological properties
of brain endothelial cells (ECs), but the molecular foundation for these properties remains …

Alzheimer's disease (AD) is the most common degenerative disorder in the elderly in
developed countries. Currently, growing evidence is pointing at endothelial dysfunction as a …

Nervous system is segregated from the body by the complex system of barriers. The CNS is
protected by (i) the blood–brain and blood-spinal cord barrier between the intracerebral and …