Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Therapeutic drug monitoring (TDM), ie, the quantification of serum or plasma concentrations
of medications for dose optimization, has proven a valuable tool for the patient-matched …

This review will concentrate on the clinical pharmacology, in particular pharmacodynamic
data, related to atypical antipsychotics, clozapine, risperidone, paliperidone, olanzapine …

Therapeutic drug monitoring studies have generally concentrated on controlling compliance
and avoiding side effects by maintaining long-term exposure to minimally effective blood …

Aims Guidance on clozapine dosing in treatment‐resistant schizophrenia is based largely
on data from White young adult males. This study aimed to investigate the pharmacokinetic …

Background Long‐term drug treatment of schizophrenia with typical antipsychotic drugs has
limitations: 25 to 33% of sufferers have illnesses that are treatment resistant. Clozapine is an …

The introduction of clozapine has given clinicians a unique agent for treating patients with
schizophrenia that is refractory to other neuroleptics. Despite its efficacy, the drug continues …

In the past, the information about the dose-clinical effectiveness of typical antipsychotics was
not complete and this led to the risk of extrapyramidal adverse effects. This, together with the …

Clozapine (Clozaril®) is a novel and unique prototype atypical, tricyclic, dibenzodiazepine-
derivative, antipsychotic agent. It has been proven effective and significantly superior to …

Using a pharmacogenetic approach in 185 schizophrenics who have been prospectively
assessed for clozapine response, we have examined the hypothesis that polymorphisms in …